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Table 1 Characteristics of participants in the genome-wide association cohorts

From: Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression

Disease categories HBV clearance ASPI CHB DC HCC HC
Sample size 275 92 93 188 214 169
Mean age ± SD 49.56 ± 8.8 46.89 ± 6.9 * 46.46 ± 5.7 ** 50.65 ± 8.4 51.34 ± 10.5 * 48.82 ± 7.1
Male/female 105/170 33/59 62/31 *** 148/40 *** 183/31 *** 73/96
ALT, U/L, mean ± SD 26.95 ± 30.42 24.5 ± 8.79 169.53 ± 243.76 *** 89.57 ± 115.79 *** 214 ± 381.67 ** 23.11 ± 7.97
AST, U/L, mean ± SD 25.89 ± 21.89 * 23.16 ± 6.45 100.04 ± 127.54 *** 102.46 ± 118.36 *** 120.51 ± 286.05 *** 22.23 ± 7.00
TBiL, μmol/L, mean ± SD 13.68 ± 9.93 12.28 ± 2.91 23.12 ± 35.60 *** 65.87 ± 83.22 *** 50.11 ± 90.93 *** 12.95 ± 4.09
DBiL, μmol/L, mean ± SD 5.86 ± 18.39 3.59 ± 1.68 9.36 ± 14.29 ** 35.15 ± 51.33 *** 25.87 ± 55.04 *** 4.54 ± 9.46
ALP, U/L, mean ± SD 74.30 ± 35.86 73.57 ± 44.58 108.89 ± 42.20 *** 132.22 ± 61.42 *** 141.63 ± 104.32 *** 70.85 ± 25.33
GGT, U/L, mean ± SD 28.34 ± 30.77 29.88 ± 21.19 88.76 ± 106.63 *** 89.94 ± 132.10 *** 158.08 ± 183.92 *** 27.58 ± 24.88
ALB, g/L, mean ± SD 43.33 ± 6.11 44.16 ± 6.71 42.40 ± 42.25 * 32.28 ± 7.13 ** 37.19 ± 7.27 *** 43.93 ± 4.96
AFP, μg/L, mean ± SD 21.39 ± 47.39 * 5.16 ± 4.79 34.00 ± 89.37 * 87.74 ± 169.83 ** 7315.22 ± 37,329.94 3.76 ± 4.34
PTA, %, mean ± SD 95.22 ± 52.69 91.67 ± 14.30 90.06 ± 21.76 63.97 ± 28.07 *** 87.31 ± 33.96 90.84 ± 18.71
PLT, 109/L, mean ± SD 147.69 ± 55.40 146.84 ± 44.51 150.27 ± 49.61 73.96 ± 45.30 *** 145.72 ± 79.24 148.94 ± 49.10
  1. Abbreviations: ASPI, asymptomatic persistence infection; CHB, chronic hepatitis B; DC, decompensated cirrhosis; HCC, hepatocellular carcinoma; HC, healthy controls; SD, standard deviation; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, direct bilirubin; ALP, alkaline phosphatase; GGT, glutamyl transpeptidase
  2. Notes: *, statistical significance of the difference between each case group and HC group (***: p = [0, 0.001], **: p = (0.001, 0.01], *: p = (0.01, 0.05]). The significances of gender and other characteristics were calculated by Fisher's exact test and ANOVA test, respectively