Table 1 Characteristics of participants in the genome-wide association cohorts

Sample size

275

92

93

188

214

169

Mean age ± SD

49.56 ± 8.8

46.89 ± 6.9 *

46.46 ± 5.7 **

50.65 ± 8.4

51.34 ± 10.5 *

48.82 ± 7.1

Male/female

105/170

33/59

62/31 ***

148/40 ***

183/31 ***

73/96

ALT, U/L, mean ± SD

26.95 ± 30.42

24.5 ± 8.79

169.53 ± 243.76 ***

89.57 ± 115.79 ***

214 ± 381.67 **

23.11 ± 7.97

AST, U/L, mean ± SD

25.89 ± 21.89 *

23.16 ± 6.45

100.04 ± 127.54 ***

102.46 ± 118.36 ***

120.51 ± 286.05 ***

22.23 ± 7.00

TBiL, μmol/L, mean ± SD

13.68 ± 9.93

12.28 ± 2.91

23.12 ± 35.60 ***

65.87 ± 83.22 ***

50.11 ± 90.93 ***

12.95 ± 4.09

DBiL, μmol/L, mean ± SD

5.86 ± 18.39

3.59 ± 1.68

9.36 ± 14.29 **

35.15 ± 51.33 ***

25.87 ± 55.04 ***

4.54 ± 9.46

ALP, U/L, mean ± SD

74.30 ± 35.86

73.57 ± 44.58

108.89 ± 42.20 ***

132.22 ± 61.42 ***

141.63 ± 104.32 ***

70.85 ± 25.33

GGT, U/L, mean ± SD

28.34 ± 30.77

29.88 ± 21.19

88.76 ± 106.63 ***

89.94 ± 132.10 ***

158.08 ± 183.92 ***

27.58 ± 24.88

ALB, g/L, mean ± SD

43.33 ± 6.11

44.16 ± 6.71

42.40 ± 42.25 *

32.28 ± 7.13 **

37.19 ± 7.27 ***

43.93 ± 4.96

AFP, μg/L, mean ± SD

21.39 ± 47.39 *

5.16 ± 4.79

34.00 ± 89.37 *

87.74 ± 169.83 **

7315.22 ± 37,329.94

3.76 ± 4.34

PTA, %, mean ± SD

95.22 ± 52.69

91.67 ± 14.30

90.06 ± 21.76

63.97 ± 28.07 ***

87.31 ± 33.96

90.84 ± 18.71

PLT, 10⁹/L, mean ± SD

147.69 ± 55.40

146.84 ± 44.51

150.27 ± 49.61

73.96 ± 45.30 ***

145.72 ± 79.24

148.94 ± 49.10