|
Disease categories
|
HBV clearance
|
ASPI
|
CHB
|
DC
|
HCC
|
HC
|
|---|
|
Sample size
|
275
|
92
|
93
|
188
|
214
|
169
|
|
Mean age ± SD
|
49.56 ± 8.8
|
46.89 ± 6.9 *
|
46.46 ± 5.7 **
|
50.65 ± 8.4
|
51.34 ± 10.5 *
|
48.82 ± 7.1
|
|
Male/female
|
105/170
|
33/59
|
62/31 ***
|
148/40 ***
|
183/31 ***
|
73/96
|
|
ALT, U/L, mean ± SD
|
26.95 ± 30.42
|
24.5 ± 8.79
|
169.53 ± 243.76 ***
|
89.57 ± 115.79 ***
|
214 ± 381.67 **
|
23.11 ± 7.97
|
|
AST, U/L, mean ± SD
|
25.89 ± 21.89 *
|
23.16 ± 6.45
|
100.04 ± 127.54 ***
|
102.46 ± 118.36 ***
|
120.51 ± 286.05 ***
|
22.23 ± 7.00
|
|
TBiL, μmol/L, mean ± SD
|
13.68 ± 9.93
|
12.28 ± 2.91
|
23.12 ± 35.60 ***
|
65.87 ± 83.22 ***
|
50.11 ± 90.93 ***
|
12.95 ± 4.09
|
|
DBiL, μmol/L, mean ± SD
|
5.86 ± 18.39
|
3.59 ± 1.68
|
9.36 ± 14.29 **
|
35.15 ± 51.33 ***
|
25.87 ± 55.04 ***
|
4.54 ± 9.46
|
|
ALP, U/L, mean ± SD
|
74.30 ± 35.86
|
73.57 ± 44.58
|
108.89 ± 42.20 ***
|
132.22 ± 61.42 ***
|
141.63 ± 104.32 ***
|
70.85 ± 25.33
|
|
GGT, U/L, mean ± SD
|
28.34 ± 30.77
|
29.88 ± 21.19
|
88.76 ± 106.63 ***
|
89.94 ± 132.10 ***
|
158.08 ± 183.92 ***
|
27.58 ± 24.88
|
|
ALB, g/L, mean ± SD
|
43.33 ± 6.11
|
44.16 ± 6.71
|
42.40 ± 42.25 *
|
32.28 ± 7.13 **
|
37.19 ± 7.27 ***
|
43.93 ± 4.96
|
|
AFP, μg/L, mean ± SD
|
21.39 ± 47.39 *
|
5.16 ± 4.79
|
34.00 ± 89.37 *
|
87.74 ± 169.83 **
|
7315.22 ± 37,329.94
|
3.76 ± 4.34
|
|
PTA, %, mean ± SD
|
95.22 ± 52.69
|
91.67 ± 14.30
|
90.06 ± 21.76
|
63.97 ± 28.07 ***
|
87.31 ± 33.96
|
90.84 ± 18.71
|
|
PLT, 109/L, mean ± SD
|
147.69 ± 55.40
|
146.84 ± 44.51
|
150.27 ± 49.61
|
73.96 ± 45.30 ***
|
145.72 ± 79.24
|
148.94 ± 49.10
|
- Abbreviations: ASPI, asymptomatic persistence infection; CHB, chronic hepatitis B; DC, decompensated cirrhosis; HCC, hepatocellular carcinoma; HC, healthy controls; SD, standard deviation; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, direct bilirubin; ALP, alkaline phosphatase; GGT, glutamyl transpeptidase
- Notes: *, statistical significance of the difference between each case group and HC group (***: p = [0, 0.001], **: p = (0.001, 0.01], *: p = (0.01, 0.05]). The significances of gender and other characteristics were calculated by Fisher's exact test and ANOVA test, respectively
