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Table 2 SNP associations with PA risk

From: Susceptibility loci for pancreatic cancer in the Brazilian population

SNP

Nearest gene

Allele (M/m)a

MAFb controls

MAFb cases

Allelic model

Codominant model

Dominant model

OR (95% CI)

p value

M/M vs M/m

M/M vs m/m

M/M vs M/m + m/m

OR (95% CI)

p value

OR (95% CI)

p value

p trend

OR (95% CI)

p value

rs11655237

LINC00673

C/T

0.13

0.14

1.06 (0.63–1.79)

0.806

1.20 (0.66–2.18)

0.537

0.57 (0.66–4.95)

0.613

0.795

1.14 (0.64–2.05)

0.646

rs2736098

TERT

G/A

0.25

0.22

0.79 (0.51–1.22)

0.302

0.68 (0.39–1.20)

0.191

0.85 (0.28–2.54)

0.781

0.361

0.71 (1.41–1.20)

0.208

rs351365

WNT2B

G/A

0.29

0.26

0.85 (0.57–1.28)

0.454

0.82 (0.47–1.41)

0.477

0.78 (0.29–2.06)

0.625

0.449

0.81 (0.48–1.36)

0.434

rs3790844

NR5A2

T/C

0.27

0.18

0.61 (0.38–0.96)

0.036

0.56 (0.32–0.99)

0.049

0.46 (0.12–1.66)

0.240

0.030

0.55 (0.32–0.94)

0.031

rs1486134

ETAA1

T/G

0.25

0.24

1.03 (0.68–1.55)

0.867

1.32 (0.45–3.88)

0.610

1.24 (0.43–3.54)

0.42

0.838

1.27 (0.45–3.54)

0.640

rs16986825

ZNRF3

C/T

0.17

0.14

0.76 (0.45–1.28)

0.309

0.83 (0.46–1.52)

0.565

0.35 (0.04–2.87)

0.331

0.318

0.78 (0.43–1.40

0.412

rs17688601

SUGCT

C/A

0.25

0.18

0.63 (0.40–1.00)

0.046

1.28 (0.40–4.16)

0.685

0.63 (0.21–1.88)

0.406

0.093

0.8 (0.27–2.32)

0.673

rs9581943

PDX1

G/A

0.36

0.31

1.22 (0.84–1.78)

0.282

0.76 (0.34–1.69)

0.505

1.22 (0.56–2.65)

0.605

0.270

0.98 (0.47–2.05)

0.971

rs1561927

MIR1208

T/C

0.24

0.32

1.47 (0.99–2.17)

0.058

1.78 (0.71–4.54)

0.222

2.44 (0.97–6.25)

0.059

0.050

2.12 (1.88–5.26

0.092

rs9854771

TP63

G/A

0.39

0.25

0.53 (0.35–0.80)

0.003

1.09 (0.45–2.70)

0.846

0.41 (0.17–0.98)

0.043

0.002

0.64 (0.28–1.47)

0.288

rs73328514

TNS3

A/T

0.10

0.15

1.56 (0.90–2.70)

0.112

1.35 (0.73–2.49)

0.333

7.94 (0.69–91.22)

0.096

0.098

1.47 (0.81–2.66)

0.203

rs7310409

HNF1A

G/A

0.41

0.49

1.41 (0.98–2.00)

0.065

2.08 (1.08–4.00)

0.029

2.04 (1.03–4.16)

0.043

0.061

2.08 (1.13–3.84)

0.018

rs1517037

GRP

C/T

0.21

0.24

1.18 (0.76–1.82)

0.449

1.35 (0.79–2.32)

0.263

0.94 (0.25–3.52)

0.932

0.434

1.30 (0.77–2.20)

0.313

rs2853677

TERT

A/G

0.46

0.37

0.70 (0.48–1.02)

0.068

0.61 (0.34–1.09)

0.100

0.53 (0.24–1.13)

0.104

0.051

0.59 (0.34–1.01)

0.055

rs2941471

HNF4G

A/G

0.44

0.35

0.64 (0.43–0.94)

0.026

0.58 (0.33–1.02)

0.063

0.44 (0.19–0.99)

0.050

0.037

0.54 (0.32–0.93)

0.027

rs6971499

LINC-PINT

A/G

0.11

0.10

1.24 (0.67–2.29)

0.485

0.89 (0.47–1.71)

0.745

–

–

0.523

–

–

rs10991043

SMC2

T/C

0.39

0.37

1.10 (0.76–1.60)

0.601

0.47 (0.22–0.98)

0.047

0.90 (0.43–1.87)

0.789

0.545

0.64 (0.33–1.27)

0.209

rs401681

TERT

C/T

0.45

0.54

1.53(1.05–2.22)

0.026

1.67 (0.86–3.24)

0.129

2.36 (1.10–5.03)

0.026

0.026

1.86 (0.99–3.50)

0.054

rs13303010

NOC2L

A/G

0.22

0.37

1.88 (1.29–2.77)

0.001

1.39 (0.58–3.33)

0.467

3.125 (1.29–7.69)

0.011

0.003

1.45 (0.97–5.05)

0.061

rs9543325

13q22.1

T/C

0.44

0.56

1.66 (1.15–2.38)

0.007

2.85 (1.51–5.26)

0.001

2.63 (1.29–5.26)

0.007

0.011

2.77 (1.56–4.02)

0.001

rs4795218

HNF1B

G/A

0.20

0.11

0.53 (0.31–0.90)

0.021

0.78 (0.15–4.02)

0.763

0.38 (0.08–1.72)

0.209

0.015

0.44(0.09–2.04)

0.295

rs7190458

BCAR1

C/T

0.07

0.08

0.88 (0.42–1.87)

0.755

0.88 (0.42–1.87)

0.755

–

–

0.657

–

–

rs10094872

MYC

A/T

0.28

0.34

1.37 (0.92–2.02)

0.111

1.55 (0.90–2.68)

0.112

1.62 (0.65–4.06)

0.295

0.145

1.57 (0.93–2.64)

0.089

rs684559

CHI3L2

G/A

0.32

0.29

1.24 (0.84–1.81)

0.270

0.80 (0.34–1.90)

0.627

1.25 (0.55–2.84)

0.586

0.448

1.04 (0.47–2.28)

0.921

rs353630

CD44

G/A

0.29

0.30

0.95 (0.64–1.39)

0.806

1.25 (0.49–3.19)

0.626

1.05 (0.42–2.63)

0.908

0.848

1.14 (0.47–2.75)

0.770

  1. Results in bold are statistically significant (p < 0.05)
  2. aM: major allele, m: minor allele for each SNP
  3. bMAF: minor allele frequency
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BMC Medical Genomics

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