Skip to main content

Table 2 SNP associations with PA risk

From: Susceptibility loci for pancreatic cancer in the Brazilian population

SNP Nearest gene Allele (M/m)a MAFb controls MAFb cases Allelic model Codominant model Dominant model
OR (95% CI) p value M/M vs M/m M/M vs m/m M/M vs M/m + m/m
OR (95% CI) p value OR (95% CI) p value p trend OR (95% CI) p value
rs11655237 LINC00673 C/T 0.13 0.14 1.06 (0.63–1.79) 0.806 1.20 (0.66–2.18) 0.537 0.57 (0.66–4.95) 0.613 0.795 1.14 (0.64–2.05) 0.646
rs2736098 TERT G/A 0.25 0.22 0.79 (0.51–1.22) 0.302 0.68 (0.39–1.20) 0.191 0.85 (0.28–2.54) 0.781 0.361 0.71 (1.41–1.20) 0.208
rs351365 WNT2B G/A 0.29 0.26 0.85 (0.57–1.28) 0.454 0.82 (0.47–1.41) 0.477 0.78 (0.29–2.06) 0.625 0.449 0.81 (0.48–1.36) 0.434
rs3790844 NR5A2 T/C 0.27 0.18 0.61 (0.38–0.96) 0.036 0.56 (0.32–0.99) 0.049 0.46 (0.12–1.66) 0.240 0.030 0.55 (0.32–0.94) 0.031
rs1486134 ETAA1 T/G 0.25 0.24 1.03 (0.68–1.55) 0.867 1.32 (0.45–3.88) 0.610 1.24 (0.43–3.54) 0.42 0.838 1.27 (0.45–3.54) 0.640
rs16986825 ZNRF3 C/T 0.17 0.14 0.76 (0.45–1.28) 0.309 0.83 (0.46–1.52) 0.565 0.35 (0.04–2.87) 0.331 0.318 0.78 (0.43–1.40 0.412
rs17688601 SUGCT C/A 0.25 0.18 0.63 (0.40–1.00) 0.046 1.28 (0.40–4.16) 0.685 0.63 (0.21–1.88) 0.406 0.093 0.8 (0.27–2.32) 0.673
rs9581943 PDX1 G/A 0.36 0.31 1.22 (0.84–1.78) 0.282 0.76 (0.34–1.69) 0.505 1.22 (0.56–2.65) 0.605 0.270 0.98 (0.47–2.05) 0.971
rs1561927 MIR1208 T/C 0.24 0.32 1.47 (0.99–2.17) 0.058 1.78 (0.71–4.54) 0.222 2.44 (0.97–6.25) 0.059 0.050 2.12 (1.88–5.26 0.092
rs9854771 TP63 G/A 0.39 0.25 0.53 (0.35–0.80) 0.003 1.09 (0.45–2.70) 0.846 0.41 (0.17–0.98) 0.043 0.002 0.64 (0.28–1.47) 0.288
rs73328514 TNS3 A/T 0.10 0.15 1.56 (0.90–2.70) 0.112 1.35 (0.73–2.49) 0.333 7.94 (0.69–91.22) 0.096 0.098 1.47 (0.81–2.66) 0.203
rs7310409 HNF1A G/A 0.41 0.49 1.41 (0.98–2.00) 0.065 2.08 (1.08–4.00) 0.029 2.04 (1.03–4.16) 0.043 0.061 2.08 (1.13–3.84) 0.018
rs1517037 GRP C/T 0.21 0.24 1.18 (0.76–1.82) 0.449 1.35 (0.79–2.32) 0.263 0.94 (0.25–3.52) 0.932 0.434 1.30 (0.77–2.20) 0.313
rs2853677 TERT A/G 0.46 0.37 0.70 (0.48–1.02) 0.068 0.61 (0.34–1.09) 0.100 0.53 (0.24–1.13) 0.104 0.051 0.59 (0.34–1.01) 0.055
rs2941471 HNF4G A/G 0.44 0.35 0.64 (0.43–0.94) 0.026 0.58 (0.33–1.02) 0.063 0.44 (0.19–0.99) 0.050 0.037 0.54 (0.32–0.93) 0.027
rs6971499 LINC-PINT A/G 0.11 0.10 1.24 (0.67–2.29) 0.485 0.89 (0.47–1.71) 0.745 0.523
rs10991043 SMC2 T/C 0.39 0.37 1.10 (0.76–1.60) 0.601 0.47 (0.22–0.98) 0.047 0.90 (0.43–1.87) 0.789 0.545 0.64 (0.33–1.27) 0.209
rs401681 TERT C/T 0.45 0.54 1.53(1.05–2.22) 0.026 1.67 (0.86–3.24) 0.129 2.36 (1.10–5.03) 0.026 0.026 1.86 (0.99–3.50) 0.054
rs13303010 NOC2L A/G 0.22 0.37 1.88 (1.29–2.77) 0.001 1.39 (0.58–3.33) 0.467 3.125 (1.29–7.69) 0.011 0.003 1.45 (0.97–5.05) 0.061
rs9543325 13q22.1 T/C 0.44 0.56 1.66 (1.15–2.38) 0.007 2.85 (1.51–5.26) 0.001 2.63 (1.29–5.26) 0.007 0.011 2.77 (1.56–4.02) 0.001
rs4795218 HNF1B G/A 0.20 0.11 0.53 (0.31–0.90) 0.021 0.78 (0.15–4.02) 0.763 0.38 (0.08–1.72) 0.209 0.015 0.44(0.09–2.04) 0.295
rs7190458 BCAR1 C/T 0.07 0.08 0.88 (0.42–1.87) 0.755 0.88 (0.42–1.87) 0.755 0.657
rs10094872 MYC A/T 0.28 0.34 1.37 (0.92–2.02) 0.111 1.55 (0.90–2.68) 0.112 1.62 (0.65–4.06) 0.295 0.145 1.57 (0.93–2.64) 0.089
rs684559 CHI3L2 G/A 0.32 0.29 1.24 (0.84–1.81) 0.270 0.80 (0.34–1.90) 0.627 1.25 (0.55–2.84) 0.586 0.448 1.04 (0.47–2.28) 0.921
rs353630 CD44 G/A 0.29 0.30 0.95 (0.64–1.39) 0.806 1.25 (0.49–3.19) 0.626 1.05 (0.42–2.63) 0.908 0.848 1.14 (0.47–2.75) 0.770
  1. Results in bold are statistically significant (p < 0.05)
  2. aM: major allele, m: minor allele for each SNP
  3. bMAF: minor allele frequency