Table 4 Some genes and their dysfunctions from the interactions of selected feature subsets of different methods
Gene | Subset | Function |
|---|---|---|
SKAP1 | 6 methods | SKAP1 encodes a T cell adaptor protein and it is involved in HCC signaling pathways [32, 33] |
EPHB1 | SVM, KNN, NN | Ephrin-B1 participates in the tumor progression through promoting the formation of new vessels of HCC [36] |
STC2 | NN, SVM, KNN | STC2 is overexpressed in HCC and acts as a potential oncoprotein [37] |
CDHR2 | NN, SVM, KNN | CDHR2 is highly expressed in HCC para-carcinoma tissue, but is weakly expressed in tumors. It is found to inhibit tumor growth [38] |
FAM134B | NN, SVM, KNN | FAM134B works as a tumor inhibitor and inhibits cancer growth in vitro and in vivo [39] |
MUC6 | RF, NN, SVM, KNN | MUC6 encodes a member of the mucin protein family. It is a biomarker gene of many cancers [40] |
PHOSPHO1 | Adaboost, NB, NN, SVM, KNN, Stepwise Regression | PHOSPHO1 is associated with hepatitis B [41] |
OXT | NN, SVM, KNN, Stepwise Regression | OXT is found to regulate cell proliferation. It is a key differential gene in nonalcoholic fatty liver disease [42] |