The association between XRCC3 rs1799794 polymorphism and cancer risk: a meta-analysis of 34 case–control studies

Liu, Weiqing; Ma, Shumin; Liang, Lei; Kou, Zhiyong; Zhang, Hongbin; Yang, Jun

doi:10.1186/s12920-021-00965-4

BMC Medical Genomics

Table 1 Characteristics of the individual studies included in the meta-analysis

From: The association between XRCC3 rs1799794 polymorphism and cancer risk: a meta-analysis of 34 case–control studies

Author	Year	Country	Ethnicity	Cancer type	Genotyping method	Control	Cases/control	Cases			Control			HWE	NOS
Author	Year	Country	Ethnicity	Cancer type	Genotyping method	Control	Cases/control	aa	ag	gg	aa	ag	gg	HWE	NOS
Mackawy	2019	Egypt	Arabian	Ovarian carcinoma	PCR–RFLP	HB	50/20	14	20	16	4	6	10	0.128	6
Pei	2018	China	Asian	Acute lymphoblastic leukemia	PCR–RFLP	PB	266/266	55	144	67	53	150	63	0.035	7
Al Zoubi	2017	Italy	Caucasian	Breast cancer	Sequencing	HB	23/16	8	14	1	11	5	0	0.459	7
De Mattia	2017	Italy	Caucasian	Hepatocellular cancer	TaqMan	HB	192/192	128	52	12	137	49	5	0.806	7
Sarwar	2017	Pakistan	Asian	Thyroid cancer	ARMS-PCR	HB	456/400	289	90	77	297	65	38	< 0.001	7
Yan	2016	China	Asian	Yhyroid carcinoma	PCR	HB	276/403	116	127	33	202	161	40	0.345	8
Zhu	2016	China	Asian	Bladder cancer	TaqMan	HB	184/260	72	53	59	69	142	49	0.111	7
Ali	2016	Saudi Arabia	Arabian	Breast cancer	PCR–RFLP	HB	143/145	102	40	1	93	28	24	< 0.001	7
Chang	2015	China	Asian	Leiomyoma	PCR–RFLP	HB	166/474	35	91	40	93	268	113	0.004	7
Chen	2015	China	Asian	Lung cancer	PCR–RFLP	HB	358/716	70	202	86	147	395	177	0.007	7
Liu	2015	China	Asian	Nasopharyngeal carcinoma	PCR–RFLP	HB	176/880	33	99	44	179	489	212	0.001	7
Su	2015	China	Asian	Breast cancer	PCR–RFLP	HB	1232/1232	239	696	297	254	668	310	0.002	8
Al Zoubi	2015	Jordan	Arabian	Breast cancer	Sequencing	HB	46/31	16	28	2	21	9	1	0.976	7
Yuan	2015	China	Asian	Papillary thyroid cancer	PCR	HB	183/367	77	84	22	184	147	36	0.406	6
Goričar	2015	Slovenia	Caucasian	Acute lymphoblastic leukemia	TaqMan	PB	121/184	89			117			≥ 0.050	8
Goričar	2015	Slovenia	Caucasian	Osteosarcoma	TaqMan	PB	79/373	47			247			ND	7
Smolkova	2014	Germany	Caucasian	Acute lymphoblastic leukaemia	TaqMan	HB	460/547	286	155	19	340	183	24	0.921	7
TSAI	2014	China	Asian	Oral cancer	PCR–RFLP	HB	788/956	155	438	195	195	532	229	< 0.001	7
He	2013	China	Asian	Lung cancer	PCR	HB	507/661	180	230	97	184	313	164	0.181	7
Zhao	2013	China	Asian	Glioma	TaqMan	HB	384/384	83	201	100	95	181	108	0.271	7
Gresner	2012	Poland	Caucasian	Head and neck cancer	PCR–RFLP	PB	81/100	45	31	5	59	34	7	0.497	8
VRAL	2011	Belgium	Caucasian	Breast cancer	PCR–RFLP or SnapShot technique	HB	343/172	220	108	15	117	52	3	0.304	5
Quaye	2009	mixed	Caucasian	Ovarian cancer	TaqMan	PB	1461/2307	940	484	37	1505	713	89	0.691	8
Andrew	2009	USA	Mixed	Bladder cancer	PCR–RFLP	PB	342/559	190			333			ND	7
Hayden	2007	Germany, Italy, Spain, Ireland,France, Czech Republic and the Irish	Caucasian	Myeloma	TaqMan	Mixed	302/257	189	100	13	153	91	13	0.911	8
Ni	2006	China	Asian	Thyroid carcinoma	PCR–RFLP	HB	191/201	66	81	44	62	94	45	0.411	7
Garcıa-Closas	2006	Poland	Caucasian	Breast cancer	ND	PB	1920/2218	1210	632	78	1386	736	96	0.891	8
Garcıa-Closas	2006	USA	Caucasian	Breast cancer	ND	PB	1564/1264	980	521	63	837	357	52	0.079	8
Wu	2006	USA	Mixed	Bladder cancer	PCR–RFLP	HB	599/595	402	185	12	398	185	12	0.072	8
Paul Pharoah ICRC-Thai	2006	Thailand	Asian	Breast cancer	ND	PB	465/389	153	217	95	135	182	72	0.441	8
Paul Pharoah SEARCH	2006	UK	Caucasian	Breast cancer	ND	PB	2790/3642	1808	889	93	2388	1113	141	0.427	8
Paul Pharoah Sheffield	2006	UK	Caucasian	Breast cancer	ND	HB	1185/1159	781	369	35	755	353	51	0.238	8
Paul Pharoah USRTS	2006	USA	Caucasian	Breast cancer	ND	Nested	718/1049	458	224	36	650	356	43	0.509	8
Auranen1	2005	US FROC	Caucasian	Ovarian cancer	TaqMan	PB	325/417	204	112	9	267	133	17	0.932	8
Auranen2	2005	UK RMH/YOV	Caucasian	Ovarian cancer	TaqMan	PB	301/1808	194	95	12	1196	535	77	0.083	8
Matullo	2005	Italy	Caucasian	Bladder cancer	PCR–RFLP	HB	316/315	207	98	11	201	102	12	0.833	7
Han	2004	USA	Caucasian	Breast cancer	TaqMan	PB	991/1291	630	322	39	865	372	54	0.084	8
Han	2004	USA	Caucasian	Endometrial cancer	TaqMan	PB	220/663	140	73	7	438	200	25	0.716	8
Jacobsen	2004	Denmark	Caucasian	Lung cancer	PCR	Nested	256/269	111	116	29	108	127	34	0.724	8
Tranah	2004	USA (NHS)	Caucasian	Colorectal adenoma	TaqMan	Nested	556/557	256	212	58	250	222	54	0.65	8
Tranah	2004	USA (HPFS)	Caucasian	Colorectal adenoma	TaqMan	Nested	376/725	180	155	31	329	303	73	0.793	8
Kuschel	2002	UK	Caucasian	Breast cancer	TaqMan	PB	1828/1808	1176	581	71	1196	535	77	0.083	8
Winsey	2000	UK	Caucasian	Melanoma skin cancer	PCR-SSP	HB	125/211	5	47	73	8	80	122	0.245	7

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