Fig. 2
From: Exonic variants undergoing allele-specific selection in cancers
Alleles under somatic selection in cancers are enriched for functionally relevant variants. The violin plots show the sampling distributions (mean and 95% confidence intervals) of the fraction of specific classes of alleles undergo different levels of somatic selection; the difference between the fractions are tested using Tukey’s honest significant difference test. a. the sampling distributions of the fractions of the deleterious alleles suggest such alleles increases in alleles under positive or negative somatic selection; b. The sampling distributions of the fractions of alleles with significantly higher frequencies in cancer population suggests such alleles increases in selected-for alleles (\({\pi }_{i}\) > 0.5); c. The sampling distributions of the fractions of alleles with significantly lower frequencies in cancer population suggest such alleles increases in selected-against alleles (\({\pi }_{i}\) < 0.5)