Fig. 6

Genetic network underlying contrast perception has significant contribution to the regulation of susceptibility to form-deprivation myopia. a Venn diagram showing overlap between genes underlying contrast sensitivity and genes regulating susceptibility to form-deprivation myopia. b Top 11 biological processes affected by the genes associated with both contrast perception (top panel) and susceptibility to form-deprivation myopia in mice (bottom panel). Outer circle shows gene ontology IDs for the biological processes; middle circle shows up- or down-regulated genes in animals with high contrast sensitivity versus animals with low contrast sensitivity (top panel), or in mice with high susceptibility to form-deprivation myopia versus mice with low susceptibility to form-deprivation myopia (bottom panel); inner circle shows activation or suppression of the corresponding biological processes, while the size of the sector corresponds to statistical significance (larger sectors correspond to smaller p-values). c Comparison of canonical signaling pathways involved in contrast perception and susceptibility to form-deprivation myopia. Vertical red line indicates p = 0.05. Vertical grey line indicates p = 0.1. Colors identify pathways associated with either contrast perception or susceptibility to form-deprivation myopia and correspond to the colors in the Venn diagrams (a)