The expression of miR-513c and miR-3163 was downregulated in tumor tissues compared with normal adjacent tissue of patients with breast cancer

Table 4 Pathways that are enriched among target genes of miRNA-3163

Nos	Gene set	Pathway name	C	E	R	FDR	p value^a
1	hsa05170	Human immunodeficiency virus 1 infection	212	3.6155	3.3191	0.081094	2.5E−04
2	hsa04110	Cell cycle	124	2.1147	3.783	0.09676	1E−03
3	hsa04114	Oocyte meiosis	124	2.1147	3.783	0.09676	1E−03
4	hsa05202	Transcriptional misregulation in cancer	186	3.1721	3.1525	0.09676	1E−03
5	hsa04010	MAPK signaling pathway	295	5.0309	2.584	0.09676	1.5E−03
6	hsa05167	Kaposi sarcoma-associated herpesvirus infection	186	3.1721	2.8373	0.2378	4.4E−03
7	hsa04340	Hedgehog signaling pathway	47	0.80154	4.9904	0.3802	8.2E−03
8	hsa04310	Wnt signaling pathway	146	2.4899	2.8114	0.49589	1E−02
9	hsa05206	MicroRNAs in cancer	150	2.5581	2.7364	0.50585	1.4E−02
10	hsa04218	Cellular senescence	160	2.7286	2.5654	0.58131	2E−02

C the total number of genes in the category, E number of expected genes in each category, R fold enrichment
^aThe Benjamini–Hochberg adjusted p value

ISSN: 1755-8794