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Table 4 Correlation of genotype with high risk phenotype

From: Retinoblastoma genetics screening and clinical management

Phenotypic features Mutation present n (%) No mutation n (%) Pearson Chi-square tests
Chi sq Significance (p value)
Optic nerve invasion
Y 11 8 1.83 0.575
N 6 11   
Recurrence
Y 9 1 5.25 0.021
N 20* 20   
Progression
Y 16 1 13.79 0.000
N 13 20   
Need for topotecan
Y 7 1 3.40 0.065
N 22 20   
Need for radiotherapy
Y 3 2 0.091 0.923
N 26 19   
  1. *Of the 20 without recurrence and with mutation, 7 had disease progression and 13 had ‘none’