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Table 3 Relationships of PDX1 and MC4R polymorphisms with T2DM risk stratified by age and sex

From: PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Gene SIP Model Genotype > 60 ≤ 60 Male Female
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
PDX1
rs9581943
Allele G 1.00   1.00   1.00   1.00  
A 0.99 (0.76–1.28) 0.919 0.84 (0.65–1.09) 0.180 0.94 (0.75–1.16) 0.544 0.87 (0.62–1.22) 0.424
Codominant GG 1.00   1.00   1.00   1.00  
AA 1.05 (0.60–1.84) 0.852 0.79 (0.45–1.38) 0.409 1.05 (0.67–1.66) 0.829 0.77 (0.37–1.60) 0.481
AG 0.86 (0.58–1.27) 0.439 0.66 (0.45–0.98) 0.039 0.73 (0.5–1.00) 0.049 0.85 (0.51–1.40) 0.516
Dominant GG 1.00   1.00   1.00   1.00  
AA-AG 0.90 (0.63–1.30) 0.580 0.69 (0.48–1.00) 0.049 0.80 (0.59–1.07) 0.130 0.83 (0.51–1.34) 0.439
Recessive AG-GG 1.00   1.00   1.00   1.00  
AA 1.14 (0.67–1.92) 0.634 0.99 (0.59–1.67) 0.982 1.24 (0.81–1.89) 0.330 0.84 (0.43–1.66) 0.620
Additive 0.98 (0.76–1.27) 0.873 0.83 (0.63–1.08) 0.156 0.94 (0.76–1.16) 0.554 0.87 (0.62–1.22) 0.421
PDX1
rs7981781
Allele G 1.00   1.00   1.00   1.00  
A 0.96 (0.75–1.23) 0.753 1.08 (0.84–1.40) 0.542 0.94 (0.76–1.16) 0.558 1.22 (0.88–1.70) 0.241
Codominant GG 1.00   1.00   1.00   1.00  
AA 1.00 (0.60–1.67) 0.999 1.23 (0.72–2.08) 0.449 0.96 (0.64–1.46) 0.856 1.46 (0.72–2.96) 0.300
AG 0.89 (0.59–1.35) 0.584 0.91 (0.61–1.35) 0.628 0.70 (0.50–0.97) 0.033 1.41 (0.83–2.39) 0.203
Dominant GG 1.00   1.00   1.00   1.00  
AA-AG 0.92 (0.62–1.36) 0.683 0.98 (0.67–1.43) 0.925 0.77 (0.56–1.05) 0.096 1.42 (0.86–2.35) 0.172
Recessive AG-GG 1.00   1.00   1.00   1.00  
AA 1.07 (0.69–1.68) 0.757 1.30 (0.81–2.09) 0.281 1.19 (0.83–1.72) 0.352 1.18 (0.63–2.20) 0.615
Additive 0.99 (0.77–1.27) 0.928 1.07 (0.83–1.38) 0.603 0.94 (0.77–1.16) 0.567 1.24 (0.88–1.75) 0.225
MC4R
rs6567160
Allele T 1.00   1.00   1.00   1.00  
C 1.32 (0.99–1.75) 0.060 0.77 (0.57–1.04) 0.091 0.96 (0.7–1.23) 0.756 1.16 (0.79–1.71) 0.460
Codominant TT 1.00   1.00   1.00   1.00  
CC 1.81 (0.91–3.58) 0.091 0.33 (0.13–0.81) 0.015 0.70 (0.37–1.32) 0.271 1.41 (0.57–3.54) 0.459
CT 1.22 (0.82–1.80) 0.322 0.96 (0.65–1.40) 0.815 1.11 (0.81–1.52) 0.522 1.08 (0.65–1.81) 0.758
Dominant TT 1.00   1.00   1.00   1.00  
CC-CT 1.31 (0.91–1.89) 0.144 0.84 (0.58–1.21) 0.340 1.04 (0.77–1.39) 0.820 1.14 (0.70–1.84) 0.596
Recessive CT-TT 1.00   1.00   1.00   1.00  
CC 1.68 (0.86–3.28) 0.129 0.33 (0.14–0.81) 0.016 0.68 (0.36–1.26) 0.215 1.37 (0.56–3.37) 0.489
Additive 1.29 (0.97–1.71) 0.077 0.77 (0.57–1.04) 0.085 0.96 (0.76–1.23) 0.760 1.14 (0.79–1.66) 0.484
MC4R
rs663129
Allele G 1.00   1.00   1.00   1.00  
A 1.32 (0.99–1.75) 0.060 0.79 (0.59–1.07) 0.125 0.98 (0.77–1.25) 0.852 1.16 (0.79–1.71) 0.460
Codominant GG 1.00   1.00   1.00   1.00  
AA 1.81 (0.91–3.58) 0.091 0.33 (0.13–0.82) 0.017 0.71 (0.38–1.33) 0.284 1.41 (0.57–3.54) 0.459
AG 1.22 (0.82–1.80) 0.322 0.99 (0.68–1.45) 0.966 1.14 (0.83–1.55) 0.424 1.08 (0.65–1.81) 0.758
Dominant GG 1.00   1.00   1.00   1.00  
AA-AG 1.31 (0.91–1.89) 0.144 0.87 (0.60–1.25) 0.441 1.06 (0.79–1.43) 0.704 1.14 (0.70–1.84) 0.596
Recessive AG-GG 1.00   1.00   1.00   1.00  
AA 1.68 (0.86–3.28) 0.129 0.33 (0.14–0.81) 0.016 0.68 (0.36–1.26) 0.215 1.37 (0.56–3.37) 0.489
Additive 1.29 (0.97–1.71) 0.077 0.78 (0.58–1.06) 0.116 0.98 (0.77–1.24) 0.854 1.14 (0.79–1.66) 0.484
MC4R
rs17782313
Allele T 1.00   1.00   1.00   1.00  
C 1.32 (0.99–1.75) 0.060 0.81 (0.60–1.09) 0.167 0.98 (0.77–1.26) 0.901 1.18 (0.80–1.74) 0.403
Codominant TT 1.00   1.00   1.00   1.00  
CC 1.81 (0.91–3.58) 0.091 0.34 (0.14–0.83) 0.018 0.71 (0.38–1.34) 0.291 1.43 (0.57–3.58) 0.443
CT 1.22 (0.82–1.80) 0.322 1.03 (0.71–1.51) 0.867 1.15 (0.84–1.58) 0.378 1.12 (0.67–1.87) 0.660
Dominant TT 1.00   1.00   1.00   1.00  
CC-CT 1.31 (0.91–1.89) 0.144 0.90 (0.62–1.30) 0.569 1.07 (0.80–1.44) 0.648 1.17 (0.73–1.90) 0.515
Recessive CT-TT 1.00   1.00   1.00   1.00  
CC 1.68 (0.86–3.28) 0.129 0.33 (0.14–0.81) 0.016 0.68 (0.36–1.26) 0.215 1.37 (0.56–3.37) 0.489
Additive 1.29 (0.97–1.71) 0.077 0.80 (0.59–1.09) 0.159 0.99 (0.77–1.25) 0.903 1.16 (0.80–1.69) 0.426
MC4R
rs12969709
Allele C 1.00   1.00   1.00   1.00  
A 1.13 (0.85–1.51) 0.406 0.78 (0.57–1.06) 0.111 0.91 (0.71–1.16) 0.449 1.03 (0.69–1.53) 0.884
Codominant CC 1.00   1.00   1.00   1.00  
AA 1.37 (0.67–2.80) 0.396 0.27 (0.10–0.75) 0.012 0.58 (0.29–1.15) 0.117 1.02 (0.39–2.70) 0.965
AC 1.12 (0.76–1.65) 0.583 0.98 (0.67–1.43) 0.900 1.06 (0.77–1.45) 0.726 1.05 (0.63–1.75) 0.867
Dominant CC 1.00   1.00   1.00   1.00  
AA-AC 1.16 (0.80–1.67) 0.442 0.85 (0.59–1.23) 0.397 0.98 (0.72–1.32) 0.879 1.04 (0.64–1.69) 0.871
Recessive AC-CC 1.00   1.00   1.00   1.00  
AA 1.31 (0.65–2.66) 0.449 0.27 (0.10–0.75) 0.012 0.57 (0.29–1.11) 0.099 1.01 (0.39–2.62) 0.989
Additive 1.14 (0.86–1.53) 0.361 0.77 (0.56–1.05) 0.098 0.91 (0.71–1.16) 0.451 1.03 (0.70–1.51) 0.893
MC4R
rs11663816
Allele T 1.00   1.00   1.00   1.00  
C 1.21 (0.90–1.61) 0.203 0.75 (0.55–1.02) 0.067 0.92 (0.72–1.17) 0.488 1.07 (0.72–1.60) 0.727
Codominant TT 1.00   1.00   1.00   1.00  
CC 1.78 (0.85–3.73) 0.127 0.31 (0.11–0.88) 0.027 0.70 (0.35–1.39) 0.304 1.44 (0.53–3.96) 0.476
CT 1.07 (0.73–1.58) 0.726 0.88 (0.60–1.28) 0.504 0.98 (0.72–1.34) 0.923 0.94 (0.57–1.57) 0.823
Dominant TT 1.00   1.00   1.00   1.00  
CC-CT 1.17 (0.81–1.68) 0.412 0.80 (0.55–1.15) 0.223 0.94 (0.70–1.27) 0.703 1.01 (0.62–1.64) 0.968
Recessive CT-TT 1.00   1.00   1.00   1.00  
CC 1.74 (0.84–3.59) 0.137 0.32 (0.11–0.91) 0.032 0.70 (0.35–1.38) 0.305 1.47 (0.54–3.98) 0.447
Additive 1.21 (0.90–1.61) 0.210 0.75 (0.55–1.03) 0.072 0.92 (0.71–1.17) 0.486 1.07 (0.73–1.57) 0.739
  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustment for age and gender
  3. Bold values indicate statistical significance (p < 0.05)