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Table 4 The associations between PDX1 and MC4R polymorphisms and the risk of T2DM stratified by smoking, drinking status

From: PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Gene SIP Model Genotype Smoking Non-smoking Drinking Non-drinking
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
PDX1
rs11619319
Allele A 1.00   1.00   1.00   1.00  
G 0.82 (0.58–1.15) 0.246 0.92 (0.70–1.21) 0.535 0.80 (0.55–1.18) 0.263 0.93 (0.71–1.22) 0.608
Codominant AA 1.00   1.00   1.00   1.00  
GG 0.75 (0.37–1.50) 0.410 0.84 (0.48–1.49) 0.558 0.67 (0.30–1.47) 0.313 0.89 (0.50–1.56) 0.676
GA 0.61 (0.34–1.09) 0.098 0.77 (0.48–1.23) 0.274 0.51 (0.27–0.97) 0.039 0.81 (0.51–1.29) 0.381
Dominant AA 1.00   1.00   1.00   1.00  
GG-GA 0.65 (0.38–1.13) 0.125 0.79 (0.51–1.23) 0.299 0.55 (0.30–1.01) 0.054 0.83 (0.54–1.29) 0.418
Recessive GA-AA 1.00   1.00   1.00   1.00  
GG 1.02 (0.57–1.83) 0.943 1.00 (0.62–1.62) 0.998 1.01 (0.63–1.63) 0.957 1.01 (0.63–1.63) 0.957
Additive 0.85 (0.61–1.19) 0.346 0.91 (0.69–1.20) 0.501 0.93 (0.71–1.23) 0.623 0.93 (0.71–1.23) 0.623
PDX1
rs2293941
Allele G 1.00   1.00   1.00   1.00  
A 0.83 (0.59–1.16) 0.274 0.91 (0.69–1.20) 0.515 0.80 (0.55–1.18) 0.264 0.94 (0.71–1.23) 0.647
Codominant GG 1.00   1.00   1.00    
AA 0.77 (0.38–1.54) 0.454 0.85 (0.48–1.50) 0.568 0.68 (0.31–1.48) 0.326 0.90 (0.51–1.57) 0.703
AG 0.64 (0.36–1.13) 0.124 0.80 (0.50–1.26) 0.331 0.51 (0.27–0.97) 0.040 0.85 (0.54–1.34) 0.477
Dominant GG 1.00   1.00   1.00   1.00  
AA-AG 0.67 (0.39–1.16) 0.156 0.81 (0.52–1.25) 0.345 0.56 (0.30–1.02) 0.056 0.86 (0.56–1.33) 0.499
Recessive AG-GG 1.00   1.00   1.00   1.00  
AA 1.02 (0.57–1.83) 0.943 0.98 (0.61–1.59) 0.939 1.03 (0.53–2.00) 0.935 1.00 (0.62–1.61) 0.986
Additive 0.86 (0.62–1.21) 0.384 0.91 (0.69–1.20) 0.511 0.79 (0.54–1.16) 0.231 0.94 (0.71–1.24) 0.654
PDX1
rs7981781
Allele G 1.00   1.00   1.00   1.00  
A 0.76 (0.54–1.07) 0.117 0.95 (0.72–1.25) 0.726 0.73 (0.50–1.08) 0.111 0.96 (0.73–1.27) 0.786
Codominant GG 1.00   1.00   1.00   1.00  
AA 0.68 (0.34–1.36) 0.277 0.92 (0.53–1.61) 0.775 0.57 (0.26–1.26) 0.167 0.94 (0.54–1.64) 0.834
AG 0.50 (0.29–0.89) 0.018 0.89 (0.57–1.41) 0.628 0.47 (0.25–0.88) 0.019 0.92 (0.59–1.44) 0.716
Dominant GG 1.00   1.00   1.00   1.00  
AA-AG 0.55 (0.32–0.95) 0.030 0.90 (0.59–1.38) 0.636 0.49 (0.27–0.90) 0.022 0.93 (0.61–1.41) 0.724
Recessive AG-GG 1.00   1.00   1.00   1.00  
AA 1.03 (0.57–1.86) 0.919 0.99 (0.61–1.60) 0.962 0.92 (0.47–1.81) 0.811 0.99 (0.61–1.60) 0.972
Additive 0.80 (0.57–1.11) 0.175 0.95 (0.72–1.26) 0.737 0.72 (0.49–1.07) 0.100 0.97 (0.74–1.27) 0.803
MC4R
rs6567160
Allele T 1.00   1.00   1.00   1.00  
C 0.92 (0.61–1.37) 0.665 1.36 (0.98–1.90) 0.068 0.90 (0.56–1.46) 0.682 1.14 (0.83–1.58) 0.416
Codominant TT 1.00   1.00   1.00   1.00  
CC 0.99 (0.33–2.93) 0.980 1.37 (0.58–3.20) 0.472 1.13 (0.29–4.41) 0.857 0.99 (0.45–2.18) 0.988
CT 0.86 (0.52–1.44) 0.569 1.60 (1.04–2.45) 0.032 0.80 (0.44–1.45) 0.460 1.34 (0.87–2.04) 0.180
Dominant TT 1.00   1.00   1.00   1.00  
CC-CT 0.88 (0.54–1.43) 0.601 1.56 (1.04–2.34) 0.031 0.83 (0.47–1.47) 0.532 1.27 (0.85–1.90) 0.237
Recessive CT-TT 1.00   1.00   1.00   1.00  
CC 1.04 (0.36–3.04) 0.942 1.16 (0.50–2.69) 0.725 1.22 (0.32–4.67) 0.776 0.89 (0.41–1.92) 0.772
Additive 0.92 (0.62–1.37) 0.688 1.37 (0.99–1.92) 0.061 0.90 (0.56–1.45) 0.673 1.15 (0.83–1.58) 0.407
MC4R
rs663129
Allele G 1.00   1.00   1.00   1.00  
A 0.93 (0.62–1.38) 0.713 1.39 (0.99–1.94) 0.053 0.96 (0.59–1.55) 0.869 1.14 (0.83–1.58) 0.416
Codominant GG 1.00   1.00   1.00   1.00  
AA 0.99 (0.33–2.95) 0.990 1.38 (0.59–3.23) 0.459 1.17 (0.30–4.54) 0.825 0.99 (0.45–2.18) 0.988
AG 0.88 (0.53–1.47) 0.624 1.64 (1.07–2.52) 0.023 0.88 (0.48–1.58) 0.660 1.34 (0.87–2.04) 0.180
Dominant GG 1.00   1.00   1.00   1.00  
AA-AG 0.89 (0.55–1.46) 0.655 1.60 (1.07–2.40) 0.023 0.91 (0.51–1.60) 0.735 1.27 (0.85–1.90) 0.237
Recessive AG-GG 1.00   1.00   1.00   1.00  
AA 1.04 (0.36–3.04) 0.942 1.16 (0.50–2.69) 0.725 1.22 (0.32–4.67) 0.776 0.89 (0.41–1.92) 0.772
Additive 0.93 (0.63–1.39) 0.734 1.40 (1.00–1.95) 0.049 0.96 (0.60–1.54) 0.855 1.15 (0.83–1.58) 0.407
MC4R
rs17782313
Allele T 1.00   1.00   1.00   1.00  
C 0.93 (0.62–1.38) 0.713 1.43 (1.02–2.00) 0.036 0.96 (0.59–1.55) 0.869 1.18 (0.85–1.63) 0.329
Codominant TT 1.00   1.00   1.00   1.00  
CC 0.99 (0.33–2.95) 0.990 1.40 (0.60–3.28) 0.439 1.17 (0.30–4.54) 0.825 1.01 (0.46–2.21) 0.977
CT 0.88 (0.53–1.47) 0.624 1.72 (1.12–2.64) 0.014 0.88 (0.48–1.58) 0.660 1.40 (0.92–2.15) 0.118
Dominant TT 1.00   1.00   1.00   1.00  
CC-CT 0.89 (0.55–1.46) 0.655 1.66 (1.11–2.50) 0.014 0.91 (0.51–1.60) 0.735 1.33 (0.89–1.99) 0.163
Recessive CT-TT 1.00   1.00   1.00   1.00  
CC 1.04 (0.36–3.04) 0.942 1.16 (0.50–2.69) 0.725 1.22 (0.32–4.67) 0.776 0.89 (0.41–1.92) 0.772
Additive 0.93 (0.63–1.39) 0.734 1.44 (1.03–2.01) 0.034 0.96 (0.60–1.54) 0.855 1.18 (0.85–1.63) 0.317
  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustment for age and gender
  3. Bold values indicate statistical significance (p < 0.05)