Skip to main content

Table. 2 Sensitivity and specificity of the detection of common fetal trisomies

From: Novel method of real-time PCR-based screening for common fetal trisomies

  Down syndrome Edward syndrome Patau syndrome Overall
Sensitivity, % 92.86 (66.13–99.82) 100 (47.82–100.00) 100 (29.24–100.00) 95.45 (77.16–99.88)
Specificity, % 98.91 (98.06–99.46) 99.80 (99.29–99.98) 99.90 (99.45–100.00) 98.60 (97.66–99.23)
LR +  85.18 (46.49–156.04) 509.00 (127.47–2032.43) 1020.00 (143.82–7234.10) 68.25 (40.25–115.73)
LR– 0.07 (0.01–0.48) 0.00 (0.00–NaN) 0.00 (0.00–NaN) 0.05 (0.01–0.31)
PPV, % 54.17 (32.82–74.45) 71.43 (29.04–96.33) 75.00 (19.41–99.37) 60.00 (42.11–76.13)
NPV, % 99.90 (99.44–100.00) 100.00 (99.64–100.00) 100.00 (99.64–100.00) 99.90 (99.44–100.00)
Accuracy, % 98.83 (97.96–99.39) 99.80 (99.30–99.98) 99.90 (99.46–100.00) 98.53 (97.59–99.18)
  1. Data in parentheses are 95% confidence intervals; LR + , positive likelihood ratio; LR-, negative likelihood ratio; PPV, positive predictive value; NPV, negative predictive value; NaN, not-a-number