Table. 2 Sensitivity and specificity of the detection of common fetal trisomies
From: Novel method of real-time PCR-based screening for common fetal trisomies
Down syndrome | Edward syndrome | Patau syndrome | Overall | |
|---|---|---|---|---|
Sensitivity, % | 92.86 (66.13–99.82) | 100 (47.82–100.00) | 100 (29.24–100.00) | 95.45 (77.16–99.88) |
Specificity, % | 98.91 (98.06–99.46) | 99.80 (99.29–99.98) | 99.90 (99.45–100.00) | 98.60 (97.66–99.23) |
LR + | 85.18 (46.49–156.04) | 509.00 (127.47–2032.43) | 1020.00 (143.82–7234.10) | 68.25 (40.25–115.73) |
LR– | 0.07 (0.01–0.48) | 0.00 (0.00–NaN) | 0.00 (0.00–NaN) | 0.05 (0.01–0.31) |
PPV, % | 54.17 (32.82–74.45) | 71.43 (29.04–96.33) | 75.00 (19.41–99.37) | 60.00 (42.11–76.13) |
NPV, % | 99.90 (99.44–100.00) | 100.00 (99.64–100.00) | 100.00 (99.64–100.00) | 99.90 (99.44–100.00) |
Accuracy, % | 98.83 (97.96–99.39) | 99.80 (99.30–99.98) | 99.90 (99.46–100.00) | 98.53 (97.59–99.18) |