Fig. 4
From: Profiling non-coding RNA levels with clinical classifiers in pediatric Crohn’s disease
Hypothesized ncRNA-miRNA Interactions. a The ncRNAs’ RN7SL2, mir1244-2, mir1244-3, and mir1244-4 log2FC in CD versus controls amongst ileal and rectal samples were calculated and combined to generate one heatmap differentiating CD versus Controls by Ward-D clustering. b Using IntaRNA, Freiburg RNA tools, thermodynamics and kinematics of the predicted binding affinities are shown below amongst one target, RN7SL2, a lncRNA, & three miRNAs, mir1244-2, mir1244-3, and mir1244-4: A: [RN7SL2]: ‘268’ -- ‘289’ & [miRNA-1244-x]: [‘28’ -- ‘48’]. The second predicted interaction located at B: [RN7SL2]: ‘195’ -- ‘199’ & [miRNA-1244-x]: [‘8’ -- ‘12’]. c The 3-D conformational location of RN7SL2, often the 7SL 1244-x]: [‘8’ -- ‘12’]. The 3-D conformational location of RN7SL2, often the 7SL component of the SRP (Signal Recognition Particle) is shown