Fig. 3From: A novel homozygous variant of COL2A1 in a Chinese male with type II collagenopathy: a case reportThree-dimensional structure model of the WT COL2A1 and p. (Ser1221Phe) mutant. The Triple helical domain and C-terminal propeptide are shown in yellow and white respectively. A Wild type protein: Serine at 1221 (red) interacts with Glycine at 1217 and Isoleucine at 1218. B Mutant protein: Serine at 1221 (red) interacts only with Proline at 1210Back to article page