Fig. 5

Gene types, location, repeat units, and patterns of MSI/LOH in the tumor-related genes of CRCs. A, B The frequency of MSI/LOH events within each type of TS, DNAR, MMR, and oncogene group. Frequency = (the number of MSI/LOH events)/(the number of loci affected within the gene type × the number of tumor samples). C The ratios of the MSI events that appeared in introns, noncoding regions and exons. Ratio = (the number of MSI events within the indicated region)/(the number of loci affected within the region × the number of tumor samples). D The ratios of the LOH events that appeared in introns, noncoding regions and 3′UTRs. Ratio = (the number of MSI events within the indicated region)/(the number of loci affected within the region × the number of tumor samples). E The frequency of MSI events grouped by the number of nucleotide repeats, including dinucleotide, trinucleotide, and tetranucleotide repeats. Rate = (the number of MSI events carrying the indicated repeats)/(the number of loci affected × the number of tumor samples). F The frequency of LOH events grouped by the number of nucleotide repeats, which includes dinucleotide, trinucleotide, and tetranucleotide repeats. Rate = (the number of MSI events carrying the indicated repeats)/(the number of loci affected × the number of tumor samples). Note that one locus with pentanucleotide repeats occurred in MSI and was excluded from this analysis. p values were obtained from χ²-test. *p < 0.05; ***p < 0.001