Skip to main content

Table 6 CYP7B1 polymorphisms related to CHD risk stratified by smoking and drinking status

From: The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

SNP ID

Model

Genotype

Smoking

Non-smoking

Drinking

Non-drinking

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

rs7836768

Allele

A

1

 

1

 

1

 

1

 
  

G

0.89 (0.65–1.23)

0.485

1.19 (0.87–1.61)

0.275

1.07 (0.68–1.71)

0.763

1.25 (0.93–1.68)

0.139

 

Codominant

AG

0.84 (0.50–1.40)

0.495

0.96 (0.60–1.54)

0.881

0.65 (0.31–1.36)

0.250

1.18 (0.75–1.85)

0.465

  

GG

0.83 (0.45–1.56)

0.565

1.51 (0.76–2.99)

0.236

1.31 (0.54–3.16)

0.546

1.71 (0.88–3.29)

0.111

  

AA

1

 

1

 

1

 

1

 
 

Dominant

AG-GG

0.84 (0.52–1.35)

0.461

1.07 (0.68–1.66)

0.781

0.81 (0.41–1.60)

0.550

1.29 (0.84–1.98)

0.247

 

Recessive

AA-AG

1

 

1

 

1

 

1

 
  

GG

0.92 (0.53–1.60)

0.774

1.07 (0.68–1.66)

0.781

1.66 (0.75–3.66)

0.209

1.55 (0.85–2.84)

0.156

 

Log-additive

–

0.90 (0.67–1.23)

0.522

1.16 (0.84–1.59)

0.370

1.07 (0.68–1.68)

0.769

1.27 (0.94–1.73)

0.119

rs6472155

Allele

A

1

 

1

 

1

 

1

 
  

G

0.83 (0.59–1.18)

0.294

1.27 (0.90–1.77)

0.171

0.99 (0.59–1.66)

0.961

1.15 (0.83–1.59)

0.387

 

Codominant

AG

0.92 (0.57–1.47)

0.724

0.93 (0.59–1.44)

0.735

1.36 (0.70–2.64)

0.371

0.84 (0.56–1.29)

0.425

  

GG

0.55 (0.23–1.31)

0.175

2.68 (0.93–7.71)

0.068

0.26 (0.03–2.21)

0.220

3.16 (1.05–9.48)

0.040

  

AA

1

 

1

 

1

 

1

 
 

Dominant

AG-GG

0.85 (0.54–1.33)

0.481

1.05 (0.68–1.60)

0.841

1.18 (0.61–2.26)

0.625

0.98 (0.65–1.47)

0.907

 

Recessive

AA-AG

1

 

1

 

1

 

1

 
  

GG

0.57 (0.25–1.32)

0.190

2.77 (0.98–7.83)

0.055

0.23 (0.03–1.18)

0.170

3.43 (1.16–10.09)

0.025

 

Log-additive

–

0.82 (0.57–1.17)

0.268

1.19 (0.83–1.69)

0.346

0.95 (0.55–1.64)

0.863

1.16 (0.83–1.63)

0.376

rs2980003

Allele

C

1

 

1

 

1

 

1

 
  

T

0.97 (0.70–1.36)

0.879

1.04 (0.77–1.41)

0.795

0.57 (0.35–0.95)

0.031

0.96 (0.72–1.30)

0.810

 

Codominant

TC

1.07 (0.66–1.72)

0.790

1.06 (0.67–1.69)

0.805

0.48 (0.23–0.97)

0.042

0.98 (0.63–1.53)

0.927

  

TT

0.86 (0.41–1.79)

0.682

1.03 (0.54–1.96)

0.928

0.44 (0.15–1.32)

0.143

0.93 (0.49–1.53)

0.833

  

CC

1

 

1

 

1

 

1

 
 

Dominant

TC-TT

1.02 (0.65–1.60)

0.933

1.05 (0.68–1.63)

0.818

0.47 (0.24–0.91)

0.025

0.97 (0.64–1.48)

0.882

 

Recessive

CC-TC

1

 

1

 

1

 

1

 
  

TT

0.83 (0.41–1.68)

0.603

1.00 (0.55–1.81)

0.995

0.61 (0.21–1.75)

0.359

0.94 (0.52–1.71)

0.849

 

Log-additive

–

0.97 (0.69–1.36)

0.857

1.03 (0.75–1.39)

0.875

0.59 (0.36–0.98)

0.041

0.97 (0.72–1.31)

0.840

  1. Bold indicate that P < 0.05 means the data are statistically significant
  2. OR, Odds ratio, 95% CI; 95% confidence intervals
  3. p values were calculated by logistic regression adjusted by age and gender
  4. p < 0.05 indicates statistical significance
Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us