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Table 6 CYP7B1 polymorphisms related to CHD risk stratified by smoking and drinking status

From: The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

SNP ID Model Genotype Smoking Non-smoking Drinking Non-drinking
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
rs7836768 Allele A 1   1   1   1  
   G 0.89 (0.65–1.23) 0.485 1.19 (0.87–1.61) 0.275 1.07 (0.68–1.71) 0.763 1.25 (0.93–1.68) 0.139
  Codominant AG 0.84 (0.50–1.40) 0.495 0.96 (0.60–1.54) 0.881 0.65 (0.31–1.36) 0.250 1.18 (0.75–1.85) 0.465
   GG 0.83 (0.45–1.56) 0.565 1.51 (0.76–2.99) 0.236 1.31 (0.54–3.16) 0.546 1.71 (0.88–3.29) 0.111
   AA 1   1   1   1  
  Dominant AG-GG 0.84 (0.52–1.35) 0.461 1.07 (0.68–1.66) 0.781 0.81 (0.41–1.60) 0.550 1.29 (0.84–1.98) 0.247
  Recessive AA-AG 1   1   1   1  
   GG 0.92 (0.53–1.60) 0.774 1.07 (0.68–1.66) 0.781 1.66 (0.75–3.66) 0.209 1.55 (0.85–2.84) 0.156
  Log-additive 0.90 (0.67–1.23) 0.522 1.16 (0.84–1.59) 0.370 1.07 (0.68–1.68) 0.769 1.27 (0.94–1.73) 0.119
rs6472155 Allele A 1   1   1   1  
   G 0.83 (0.59–1.18) 0.294 1.27 (0.90–1.77) 0.171 0.99 (0.59–1.66) 0.961 1.15 (0.83–1.59) 0.387
  Codominant AG 0.92 (0.57–1.47) 0.724 0.93 (0.59–1.44) 0.735 1.36 (0.70–2.64) 0.371 0.84 (0.56–1.29) 0.425
   GG 0.55 (0.23–1.31) 0.175 2.68 (0.93–7.71) 0.068 0.26 (0.03–2.21) 0.220 3.16 (1.05–9.48) 0.040
   AA 1   1   1   1  
  Dominant AG-GG 0.85 (0.54–1.33) 0.481 1.05 (0.68–1.60) 0.841 1.18 (0.61–2.26) 0.625 0.98 (0.65–1.47) 0.907
  Recessive AA-AG 1   1   1   1  
   GG 0.57 (0.25–1.32) 0.190 2.77 (0.98–7.83) 0.055 0.23 (0.03–1.18) 0.170 3.43 (1.16–10.09) 0.025
  Log-additive 0.82 (0.57–1.17) 0.268 1.19 (0.83–1.69) 0.346 0.95 (0.55–1.64) 0.863 1.16 (0.83–1.63) 0.376
rs2980003 Allele C 1   1   1   1  
   T 0.97 (0.70–1.36) 0.879 1.04 (0.77–1.41) 0.795 0.57 (0.35–0.95) 0.031 0.96 (0.72–1.30) 0.810
  Codominant TC 1.07 (0.66–1.72) 0.790 1.06 (0.67–1.69) 0.805 0.48 (0.23–0.97) 0.042 0.98 (0.63–1.53) 0.927
   TT 0.86 (0.41–1.79) 0.682 1.03 (0.54–1.96) 0.928 0.44 (0.15–1.32) 0.143 0.93 (0.49–1.53) 0.833
   CC 1   1   1   1  
  Dominant TC-TT 1.02 (0.65–1.60) 0.933 1.05 (0.68–1.63) 0.818 0.47 (0.24–0.91) 0.025 0.97 (0.64–1.48) 0.882
  Recessive CC-TC 1   1   1   1  
   TT 0.83 (0.41–1.68) 0.603 1.00 (0.55–1.81) 0.995 0.61 (0.21–1.75) 0.359 0.94 (0.52–1.71) 0.849
  Log-additive 0.97 (0.69–1.36) 0.857 1.03 (0.75–1.39) 0.875 0.59 (0.36–0.98) 0.041 0.97 (0.72–1.31) 0.840
  1. Bold indicate that P < 0.05 means the data are statistically significant
  2. OR, Odds ratio, 95% CI; 95% confidence intervals
  3. p values were calculated by logistic regression adjusted by age and gender
  4. p < 0.05 indicates statistical significance