Table 1 A total of 434 DEGs were identified from TCGA and GEO datasets, including 149 upregulated and 285 downregulated genes in pRCC compared with normal tissues

Upregulated genes (n = 149)

UGCG, TKT, HSPB1, TMSB10, HSPB8, ANXA1, MMP7, MET, ALOX5, RNASE6, GPNMB, ITGA3, FCGR2B, SEL1L3, DDB2, MGAT4B, EVI2A, HS3ST1, C3, FAS, TNFSF10, CRYAB, BCHE, C3AR1, PPAP2C, ELF3, HLA-J, LY86, PIGR, EZR, KDELC1, LPXN, SNX10, CXCL8, PERP, AHR, LACTB2, IFI27, TMEM140, CCDC109B, TNFAIP6, CYP3A5, SOX9, SNAP25, CTSS, PLS1, ABCC3, KRT8, CASP1, CORO1C, CAPG, ENO2, OLR1, SEZ6L2, NEFL, LIPA, GBP2, IL18, GALNT12, CDH6, ITGB8, ANG, ITGB2, PRUNE2, RCN1, PSMB8, APOL1, QPCT, SCEL, TES, PLOD3, TIMP1, HAVCR1, RAB31, THEMIS2, ALDOA, TNFRSF12A, C17orf62, FUT8, S100A11, TNFSF13, MVP, RGS1, CD14, ANXA2, CD37, TYROBP, CCL18, SERPINE2, PNMA2, GPR183, PYGL, ALOX5AP, TREM2, CLDN3, IGFBP6, LGALS3, WIPI1, CLU, ARL6IP5, CORO1A, EVI2B, EMP3, TPK1, TNFAIP8, NLGN1, HLA-G, ISG20, CXCL1, ARPC1B, HRH1, PLA2G7, KRT18, C1QB, RHBDF2, BAZ1A, TFPI, VCAN, GLRB, AKR1C1, IL32, NIT2, HLA-B, RNASET2, LAPTM5, CXCL6, SLC34A2, FDXR, PLA2G16, CLDN1, CAV2, IGSF6, P4HB, LCN2, FZD1, C1QA, GPX1, AHNAK2, B4GALT5, ANXA4, TFPI2, APBB1IP, PSMB10, BHLHE41, CNTN6, APOC1, TMEM176B, PSMB9, CTSC

Downregulated genes (n = 285)

PTGER3, ERBB4, RALYL, XPNPEP2, SPINK1, SLC4A1, CUBN, GSTA1, MPPED2, KLK6, HMGCS2, ITIH5, HOXD11, SH3BP4, HRG, MMRN2, CALB1, NR2F1, HSD11B2, TUBAL3, TIMP3, CNN1, GPC5, TEK, PLN, A1CF, DACH1, GHR, TMEM30B, BHMT, ANGPTL3, TFCP2L1, PAK6, SLC16A5, ALDH4A1, TSPAN8, MEIS2, C8orf4, SLC22A6, BDKRB2, IDH2, EFHD1, RAP1GAP, CRHBP, ASS1, AQP2, DAO, TBX2, TSPAN7, PTPRB, FGF1, APLNR, TFAP2B, ITGA8, CEL, NPHS1, COLEC11, KHK, ESRRG, PBLD, GRHL2, STON1, NDNF, EGFL7, SLC34A1, STAP1, ACSF2, MT1G, ASAP2, WT1, SLC22A8, IL13RA2, AOC3, GJA4, GC, ALDH6A1, STC1, SEMA3G, TCF21, MEIS1, EGF, ANK2, THY1, HSPA2, TYRP1, MAN1C1, TMPRSS4, PHGDH, MYH11, ITPR1, PCK1, SLC26A4, ADH1C, DPYS, IGFBP2, NPY1R, PAPPA2, TIE1, CLDN10, AGTR1, SCNN1B, PODXL, RAMP3, CLIC5, AFM, ACPP, GIMAP6, MME, RHCG, CYP4A11, GRB14, MT1X, ARAP3, PLS3, C7, MST1L, PDK4, CLCNKB, SLC7A8, PDE1A, IGFBP5, TMPRSS2, CTGF, RERGL, ANGPT1, PTGER4, EMX1, EFEMP1, ATP6V0A4, ASPN, LHX1, CDH3, CD34, L1CAM, NR3C2, TAGLN, EMCN, BLNK, MGAM, CHGB, KDR, PACRG, HPD, SYNDIG1, GRAMD1B, PDE2A, NRN1, SPAG5, GATA3, PLCG2, KCNJ1, NFASC, SLC12A3, CLDN5, PTGDS, TCEAL2, SLC5A12, TLN2, ACADSB, NTRK2, MFGE8, CA4, EPN3, FABP1, PLAT, CYP4F2, S1PR1, HOXD10, IL1R2, SH3BP5, NELL1, AQP3, FGF9, PLCL1, NPHS2, CALML3, SLC12A1, SLC7A9, AZGP1, SLC43A1, CXCL12, DDN, APOD, LDB2, EHD3, PVALB, FOXI1, TBX3, SPARCL1, RASL11B, FAM184A, PRSS23, NTF3, SORD, FBP1, PDZD2, SPTBN2, LHFP, SUSD4, DDC, GSTM3, HBB, KNG1, CASR, TFAP2A, SRPX, COX7A1, MECOM, CDKN1C, GAS1, PEG3, PCDH9, FECH, PLG, SOCS2, ARG2, EIF1AY, HAO2, RNF186, MT1F, ERVMER34-1, PPP1R16B, DCXR, TGFBR3, UMOD, ADH1B, LPL, PPP2R2B, DIO1, ELF5, OLFML3, SIM2, CSRP2, RHOBTB3, HRC, GPC3, FCN3, PDGFRA, FRZB, CLDN8, FAM107A, NES, FXYD1, SLC5A2, REN, G6PC, ADH6, MT1H, GPRC5B, RAMP2, KIAA1462, TGFB1I1, KDM5D, ALB, CEACAM1, ALDOB, DCN, PLVAP, EPAS1, CKMT2, SLC13A3, CPN2, AGMAT, ASB9, PTH1R, UGT8, SNAI2, CYFIP2, GAD1, KLHL3, ATP6V1B1, DUSP9, SERPINA5, TM4SF5, SFRP1, OLFML1, CDH5, SELENBP1, PIPOX, PRODH2, FOLR3, PARM1, FBLN5, EFS, WLS