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Table 2 Odds ratios of ANRIL tag SNPs for CAD by multivariable logistic regression analysis

From: Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors

SNP

Model

Cases (n)

Controls (n)

Adjusted OR (95% CI)

P value

rs1004638

Genotype

TT (Ref.)

27

68

1

 

AT

206

208

2.13 (1.34–3.40)

0.001

AA

268

225

2.50 (1.58–3.95)

< 0.001

AT + AA

474

433

2.32 (1.49–3.62)

< 0.001

Ptrend

    

0.008

Allele

T (Ref.)

260

344

1

 

A

742

658

1.39 (1.15–1.69)

< 0.001

rs1333048

Genotype

AA (Ref.)

104

141

1

 

AC

249

259

1.38 (1.01–1.88)

0.044

CC

147

97

2.02 (1.40–2.91)

< 0.001

AC + CC

396

356

1.56 (1.16–2.09)

0.003

Ptrend

    

0.001

Allele

A (Ref.)

457

541

1

 

C

543

453

1.40 (1.17–1.67)

< 0.001

rs1333050

Genotype

CC (Ref.)

101

124

1

 

CT

259

265

1.21 (0.88–1.66)

0.242

TT

142

109

1.58 (1.09–2.28)

0.015

CT + TT

401

374

1.32 (0.97–1.78)

0.074

Ptrend

    

0.027

Allele

C (Ref.)

461

513

1

 

T

541

483

1.24 (1.04–1.48)

0.018

  1. Ref.: reference variable; CAD: coronary artery disease; OR: odds ratio; CI: confidence interval. Trend test was examined by χ2 test (linear-by-linear association)