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Table 7 The associations of the genotype within clinical characteristics

From: Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps

Clinical feature Characteristic Genotype Control Case OR (95% CI) P-value
Sex Female C/C 155 95 Ref  
C/T 89 54 0.99 (0.65–1.5) 0.962720
T/T 17 51 4.89 (2.67–8.97) 2.72e−07
Male C/C 150 120 Ref  
C/T 72 58 1.01 (0.66–1.53) 0.97430
T/T 17 41 3.01 (1.63–5.57) 0.00043
Age  < 45 C/C 142 50 Ref  
C/T 71 23 0.92 (0.52–1.63) 0.7744
T/T 16 13 2.31 (1.04–5.13) 0.0404
 ≥ 45 C/C 163 165 Ref  
C/T 90 89 0.98 (0.68–1.41) 0.900
T/T 18 79 4.34 (2.49–7.56) 2.30e−07
Addictiona No C/C 234 180 Ref  
C/T 131 95 0.94 (0.68–1.31) 0.72454
T/T 22 78 4.61 (2.76–7.69) 4.76e−09
Yes C/C 71 35 Ref  
C/T 30 17 1.15 (0.56–2.36) 0.704302
T/T 12 14 2.37 (0.99–5.65) 0.052515
  1. Bold indicates a p-value less than 0.05 is statistically significant
  2. aType of addiction = smoking (cigarette, hookah, opium)