Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps

Table 7 The associations of the genotype within clinical characteristics

Clinical feature	Characteristic	Genotype	Control	Case	OR (95% CI)	P-value
Sex	Female	C/C	155	95	Ref
		C/T	89	54	0.99 (0.65–1.5)	0.962720
		T/T	17	51	4.89 (2.67–8.97)	2.72e−07
	Male	C/C	150	120	Ref
		C/T	72	58	1.01 (0.66–1.53)	0.97430
		T/T	17	41	3.01 (1.63–5.57)	0.00043
Age	< 45	C/C	142	50	Ref
		C/T	71	23	0.92 (0.52–1.63)	0.7744
		T/T	16	13	2.31 (1.04–5.13)	0.0404
	≥ 45	C/C	163	165	Ref
		C/T	90	89	0.98 (0.68–1.41)	0.900
		T/T	18	79	4.34 (2.49–7.56)	2.30e−07
Addiction^a	No	C/C	234	180	Ref
		C/T	131	95	0.94 (0.68–1.31)	0.72454
		T/T	22	78	4.61 (2.76–7.69)	4.76e−09
	Yes	C/C	71	35	Ref
		C/T	30	17	1.15 (0.56–2.36)	0.704302
		T/T	12	14	2.37 (0.99–5.65)	0.052515

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