Table 5 The SNPs of CTNNA3 associated with susceptibility of type 2 diabetes in the subgroup tests (smoking and drinking)
SNP ID | Model | Genotype | Smoking | Drinking | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
No (N = 454) | Yes (N = 342) | No (N = 528) | Yes (N = 236) | |||||||
rs10822745 | Allele | C | 0.96 (0.70–1.31) | 0.777 | 1.11 (0.85–1.46) | 0.447 | 1.13 (0.78–1.63) | 0.524 | 1.05 (0.80–1.39) | 0.715 |
T | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | CC | 0.79 (0.40–1.56) | 0.500 | 1.26 (0.73–2.17) | 0.407 | 1.26 (0.57–2.76) | 0.568 | 0.98 (0.57–1.69) | 0.954 | |
CT | 1.25 (0.76–2.05) | 0.377 | 1.11 (0.72–1.71) | 0.628 | 1.21 (0.68–2.14) | 0.518 | 1.43 (0.93–2.21) | 0.107 | ||
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | CC-CT | 1.13 (0.70–1.8) | 0.619 | 1.15 (0.77–1.73) | 0.488 | 1.22 (0.71–2.11) | 0.476 | 1.28 (0.86–1.91) | 0.230 | |
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | CC | 0.69 (0.38–1.27) | 0.233 | 1.18 (0.73–1.91) | 0.496 | 1.12 (0.55–2.27) | 0.750 | 0.80 (0.50–1.30) | 0.375 | |
CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 0.95 (0.68–1.33) | 0.773 | 1.12 (0.86–1.46) | 0.403 | 1.14 (0.78–1.66) | 0.505 | 1.05 (0.79–1.37) | 0.753 | |
rs7920624 | Allele | A | 1.01 (0.74–1.39) | 0.931 | 0.95 (0.73–1.25) | 0.733 | 1.10 (0.77–1.59) | 0.598 | 0.99 (0.75–1.29) | 0.921 |
T | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | AA | 1.03 (0.54–1.97) | 0.918 | 0.89 (0.52–1.51) | 0.659 | 1.23 (0.60–2.53) | 0.574 | 0.97 (0.56–1.65) | 0.899 | |
AT | 1.52 (0.88–2.63) | 0.131 | 1.02 (0.65–1.60) | 0.943 | 1.36 (0.73–2.55) | 0.334 | 1.37 (0.86–2.19) | 0.182 | ||
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | AA-AT | 1.36 (0.81–2.27) | 0.249 | 0.97 (0.63–1.49) | 0.898 | 1.31 (0.73–2.36) | 0.361 | 1.22 (0.79–1.89) | 0.363 | |
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | AA | 0.77 (0.46–1.31) | 0.342 | 0.88 (0.56–1.37) | 0.567 | 1.01 (0.56–1.83) | 0.978 | 0.78 (0.50–1.23) | 0.286 | |
AT-TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.02 (0.74–1.42) | 0.892 | 0.94 (0.72–1.23) | 0.674 | 1.11 (0.78–1.59) | 0.563 | 0.99 (0.75–1.31) | 0.937 | |
rs2441727 | Allele | A | 1.01 (0.67–1.53) | 0.953 | 0.79 (0.56–1.10) | 0.154 | 0.97 (0.62–1.51) | 0.896 | 0.80 (0.57–1.12) | 0.191 |
G | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | AA | 3.08 (0.36–6.41) | 0.305 | 1.32 (0.41–4.29) | 0.645 | 0.67 (0.15–2.95) | 0.599 | 2.60 (0.57–5.82) | 0.215 | |
AG | 0.88 (0.55–1.42) | 0.607 | 0.61 (0.41–0.92) | 0.018* | 1.08 (0.63–1.87) | 0.778 | 0.63 (0.42–0.94) | 0.025* | ||
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | AA-AG | 0.94 (0.58–1.50) | 0.780 | 0.65 (0.44–0.97) | 0.034* | 1.04 (0.61–1.76) | 0.892 | 0.69 (0.46–1.03) | 0.071 | |
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | AA | 0.82 (0.38–1.34) | 0.287 | 0.57 (0.49–1.06) | 0.448 | 0.65 (0.15–2.83) | 0.570 | 0.27 (0.68–1.83) | 0.144 | |
AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 0.93 (0.66–1.55) | 0.963 | 0.75 (0.54–1.06) | 0.108 | 0.98 (0.62–1.56) | 0.947 | 0.83 (0.58–1.17) | 0.281 | |
rs7914287 | Allele | T | 1.36 (0.97–1.91) | 0.078 | 2.36 (1.01–4.82) | 0.023* | 1.20 (0.81–1.77) | 0.368 | 1.41 (1.04–2.91) | 0.025* |
C | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | TT | 1.91 (0.87–4.21) | 0.109 | 2.50 (1.18–5.32) | 0.017* | 1.33 (0.55–3.20) | 0.527 | 2.11 (1.34–5.20) | 0.008* | |
TC | 1.29 (0.80–2.07) | 0.302 | 1.06 (0.71–1.58) | 0.788 | 1.21 (0.70–2.09) | 0.501 | 1.08 (0.72–1.62) | 0.721 | ||
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | TT-TC | 1.39 (0.89–2.19) | 0.152 | 1.23 (0.83–1.81) | 0.299 | 1.23 (0.73–2.07) | 0.436 | 1.28 (0.86–1.90) | 0.219 | |
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | TT | 1.69 (0.79–3.60) | 0.175 | 2.44 (1.18–5.05) | 0.016* | 1.21 (0.52–2.79) | 0.655 | 2.00 (1.33–4.77) | 0.008* | |
TC-CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.35 (0.96–1.89) | 0.089 | 1.34 (0.99–1.80) | 0.055 | 1.17 (0.79–1.73) | 0.428 | 1.41 (1.04–1.91) | 0.027* | |