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Table 5 The SNPs of CTNNA3 associated with susceptibility of type 2 diabetes in the subgroup tests (smoking and drinking)

From: CTNNA3 genetic polymorphism may be a new genetic signal of type 2 diabetes in the Chinese Han population: a case control study

SNP ID Model Genotype Smoking Drinking
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
No (N = 454) Yes (N = 342) No (N = 528) Yes (N = 236)
rs10822745 Allele C 0.96 (0.70–1.31) 0.777 1.11 (0.85–1.46) 0.447 1.13 (0.78–1.63) 0.524 1.05 (0.80–1.39) 0.715
   T 1.00   1.00   1.00   1.00  
  Genotype CC 0.79 (0.40–1.56) 0.500 1.26 (0.73–2.17) 0.407 1.26 (0.57–2.76) 0.568 0.98 (0.57–1.69) 0.954
   CT 1.25 (0.76–2.05) 0.377 1.11 (0.72–1.71) 0.628 1.21 (0.68–2.14) 0.518 1.43 (0.93–2.21) 0.107
   TT 1.00   1.00   1.00   1.00  
  Dominant CC-CT 1.13 (0.70–1.8) 0.619 1.15 (0.77–1.73) 0.488 1.22 (0.71–2.11) 0.476 1.28 (0.86–1.91) 0.230
   TT 1.00   1.00   1.00   1.00  
  Recessive CC 0.69 (0.38–1.27) 0.233 1.18 (0.73–1.91) 0.496 1.12 (0.55–2.27) 0.750 0.80 (0.50–1.30) 0.375
   CT-TT 1.00   1.00   1.00   1.00  
  Log-additive 0.95 (0.68–1.33) 0.773 1.12 (0.86–1.46) 0.403 1.14 (0.78–1.66) 0.505 1.05 (0.79–1.37) 0.753
rs7920624 Allele A 1.01 (0.74–1.39) 0.931 0.95 (0.73–1.25) 0.733 1.10 (0.77–1.59) 0.598 0.99 (0.75–1.29) 0.921
   T 1.00   1.00   1.00   1.00  
  Genotype AA 1.03 (0.54–1.97) 0.918 0.89 (0.52–1.51) 0.659 1.23 (0.60–2.53) 0.574 0.97 (0.56–1.65) 0.899
   AT 1.52 (0.88–2.63) 0.131 1.02 (0.65–1.60) 0.943 1.36 (0.73–2.55) 0.334 1.37 (0.86–2.19) 0.182
   TT 1.00   1.00   1.00   1.00  
  Dominant AA-AT 1.36 (0.81–2.27) 0.249 0.97 (0.63–1.49) 0.898 1.31 (0.73–2.36) 0.361 1.22 (0.79–1.89) 0.363
   TT 1.00   1.00   1.00   1.00  
  Recessive AA 0.77 (0.46–1.31) 0.342 0.88 (0.56–1.37) 0.567 1.01 (0.56–1.83) 0.978 0.78 (0.50–1.23) 0.286
   AT-TT 1.00   1.00   1.00   1.00  
  Log-additive 1.02 (0.74–1.42) 0.892 0.94 (0.72–1.23) 0.674 1.11 (0.78–1.59) 0.563 0.99 (0.75–1.31) 0.937
rs2441727 Allele A 1.01 (0.67–1.53) 0.953 0.79 (0.56–1.10) 0.154 0.97 (0.62–1.51) 0.896 0.80 (0.57–1.12) 0.191
   G 1.00   1.00   1.00   1.00  
  Genotype AA 3.08 (0.36–6.41) 0.305 1.32 (0.41–4.29) 0.645 0.67 (0.15–2.95) 0.599 2.60 (0.57–5.82) 0.215
   AG 0.88 (0.55–1.42) 0.607 0.61 (0.41–0.92) 0.018* 1.08 (0.63–1.87) 0.778 0.63 (0.42–0.94) 0.025*
   GG 1.00   1.00   1.00   1.00  
  Dominant AA-AG 0.94 (0.58–1.50) 0.780 0.65 (0.44–0.97) 0.034* 1.04 (0.61–1.76) 0.892 0.69 (0.46–1.03) 0.071
   GG 1.00   1.00   1.00   1.00  
  Recessive AA 0.82 (0.38–1.34) 0.287 0.57 (0.49–1.06) 0.448 0.65 (0.15–2.83) 0.570 0.27 (0.68–1.83) 0.144
   AG-GG 1.00   1.00   1.00   1.00  
  Log-additive 0.93 (0.66–1.55) 0.963 0.75 (0.54–1.06) 0.108 0.98 (0.62–1.56) 0.947 0.83 (0.58–1.17) 0.281
rs7914287 Allele T 1.36 (0.97–1.91) 0.078 2.36 (1.01–4.82) 0.023* 1.20 (0.81–1.77) 0.368 1.41 (1.04–2.91) 0.025*
   C 1.00   1.00   1.00   1.00  
  Genotype TT 1.91 (0.87–4.21) 0.109 2.50 (1.18–5.32) 0.017* 1.33 (0.55–3.20) 0.527 2.11 (1.34–5.20) 0.008*
   TC 1.29 (0.80–2.07) 0.302 1.06 (0.71–1.58) 0.788 1.21 (0.70–2.09) 0.501 1.08 (0.72–1.62) 0.721
   CC 1.00   1.00   1.00   1.00  
  Dominant TT-TC 1.39 (0.89–2.19) 0.152 1.23 (0.83–1.81) 0.299 1.23 (0.73–2.07) 0.436 1.28 (0.86–1.90) 0.219
   CC 1.00   1.00   1.00   1.00  
  Recessive TT 1.69 (0.79–3.60) 0.175 2.44 (1.18–5.05) 0.016* 1.21 (0.52–2.79) 0.655 2.00 (1.33–4.77) 0.008*
   TC-CC 1.00   1.00   1.00   1.00  
  Log-additive 1.35 (0.96–1.89) 0.089 1.34 (0.99–1.80) 0.055 1.17 (0.79–1.73) 0.428 1.41 (1.04–1.91) 0.027*
  1. OR, odds ratio; CI, confidence interval
  2. p < 0.05, bold text and '*' indicate statistical significance
  3. “–” indicates Log-additive model