Table 2 Clinical parameters of the first proband after GH treatment
From: Molecular genetic analysis and growth hormone response in patients with syndromic short stature
CA (year) | BA (year) | Height (cm) | Weight (kg) | GH (mg/kg/w) | IGF-1 ng/mL | HbA1c (3.6–6.0%) | INS (2.6–11.8 µU/mL) | T3 (nmol/L) | T4 (nmol/L) | FT3 (pmol/L) | FT4 (pmol/L) | TSH (mIU/L) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
4–3/12 | 2.5 | 85.8 (− 5.05SD) | 13.8 (− 1.74SD) | 0.2 | 88.9 (49–283) | 4.7 | 1.8 | 3.0 (1.4–3.8) | 120.3 (76.6–189.0) | 7.1 (3.7–8.5) | 17.8 (12.3–22.8) | 2.91 (0.7–5.97) |
4–4/12 | 86.8 (− 4.93SD) | 13.0 (− 2.38SD) | 0.2 | 124 (49–283) | 5.2 | / | 3.4 (1.4–3.8) | 145.9 (76.6–189.0) | 7.9 (3.7–8.5) | 21.0 (12.3–22.8) | 2.95 (0.7–5.97) | |
4–6/12 | 87.1 (− 5.07SD) | 14.0 (− 1.86SD) | 0.2 | 93.9 (49–283) | 4.8 | 4.0 | 3.1 (1.4–3.8) | 112.1 (76.6–189.0) | 8.1 (3.7–8.5) | 18.3 (12.3–22.8) | 2.72 (0.7–5.97) | |
4–9/12 | 3 | 90.0 (− 4.71SD) | 40.5 (− 1.81SD) | 0.2 | 107 (49–283) | 5.2 | 2.7 | 2.9 (1.4–3.8) | 142.2 (76.6–189.0) | 6.7 (3.7–8.5) | 20.1 (12.3–22.8) | 2.30 (0.7–5.97) |
5 | 92.4 (− 4.42SD) | 16.95 (− 0.67SD) | 0.2 | 245 (50–286) | 4.5 | 2.9 | 3.4 (1.4–3.8) | 123.8 (76.6–189.0) | 8.2 (3.7–8.5) | 19.2 (12.3–22.8) | 4.19 (0.7–5.97) | |
5–4/12 | 4 | 93.4 (− 4.59SD) | 16.0 (− 1.44SD) | 0.2 | 291↑ (50–286) | 5.3 | 4.9 | 3.2↑ (1.3–3.1) | 154.9 (66.0–181.0) | 8.1 (3.0–9.1) | 22.4↑ (12.0–22.0) | 1.93 (0.27–4.2) |
5–7/12 | 95.3 (− 4.46SD) | 17.5 (− 0.93SD) | 0.3 | 149 (50–286) | 5.1 | 2.1 | 3.3↑ (1.3–3.1) | 157.0 (66.0–181.0) | 8.3 (3.0–9.1) | 23.1↑ (12.0–22.0) | 3.21 (0.27–4.2) | |
5–10/12 | 4.5 | 97.5 (− 4.19SD) | 18.0 (− 0.88SD) | 0.3 | 473↑ (50–286) | 5.3 | 9.1 | 3.6 (1.3–3.1) | 171.4 (66.0–181.0) | 8.3 (3.0–9.1) | 27.2↑ (12.0–22.0) | 1.46 (0.27–4.2) |
6–1/12 | 99.6 (− 3.96SD) | 19.0 (− 0.65SD) | 0.2 | 416↑ (52–297) | 5.1 | 5.6 | 3.7 (1.3–3.1) | 148.0 (66.0–181.0) | 8.6 (3.0–9.1) | 22.1↑ (12.0–22.0) | 1.61 (0.27–4.2) | |
6–4/12 | 5 | 100.4 (− 4.02SD) | 18.0 (− 1.25SD) | 0.2 | 304 (52–297) | 5.1 | 4.2 | 3.2↑ (1.3–3.1) | 128.7 (66.0–181.0) | 7.7 (3.0–9.1) | 19.4 (12.0–22.0) | 1.87 (0.27–4.2) |