Table 3 Associations between IL-6 polymorphisms and ONFH susceptibility
From: An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development
SNP | Model | Genotype | Control | Case | OR (95% CI) | p |
|---|---|---|---|---|---|---|
rs2069837 | Allele | A | 873 (77.3%) | 925 (81.7%) | 1.00 | |
G | 257 (22.7%) | 207 (18.3%) | 0.76 (0.62–0.93) | 0.009 | ||
Codominant | AA | 336 (59.5%) | 378 (66.8%) | 1.00 | ||
GG | 28 (5%) | 19 (3.4%) | 0.61 (0.33–1.11) | 0.103 | ||
AG | 201 (35.6%) | 169 (29.9%) | 0.75 (0.58–0.96) | 0.023 | ||
Dominant | AA | 336 (59.5%) | 378 (66.8%) | 1.00 | ||
GG + AG | 229 (40.5%) | 188 (33.2%) | 0.73 (0.57–0.93) | 0.011 | ||
Recessive | AA + AG | 537 (95%) | 547 (96.6%) | 1.00 | ||
GG | 28 (5%) | 19 (3.4%) | 0.67 (0.37–1.21) | 0.186 | ||
Additive | / | 0.76 (0.62–0.93) | 0.009 | |||
rs13306435 | Allele | T | 1089 (96.2%) | 1094 (96.6%) | 1.00 | |
A | 43 (3.8%) | 38 (3.4%) | 0.88 (0.56–1.37) | 0.572 | ||
Codominant | TT | 524 (92.6%) | 528 (93.3%) | 1.00 | ||
AA | 1 (0.2%) | 0 (0%) | / | / | ||
AT | 41 (7.2%) | 38 (6.7%) | 0.92 (0.58–1.45) | 0.712 | ||
Dominant | TT | 524 (92.6%) | 528 (93.3%) | 1.00 | ||
AA + AT | 42 (7.4%) | 38 (6.7%) | 0.90 (0.57–1.41) | 0.634 | ||
Recessive | TT + AT | 565 (99.8%) | 566 (100%) | 1.00 | ||
AA | 1 (0.2%) | 0 (0%) | / | / | ||
Additive | / | 0.88 (0.56–1.37) | 0.560 |