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Table 3 Associations between IL-6 polymorphisms and ONFH susceptibility

From: An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

SNP Model Genotype Control Case OR (95% CI) p
rs2069837 Allele A 873 (77.3%) 925 (81.7%) 1.00  
  G 257 (22.7%) 207 (18.3%) 0.76 (0.62–0.93) 0.009
Codominant AA 336 (59.5%) 378 (66.8%) 1.00  
  GG 28 (5%) 19 (3.4%) 0.61 (0.33–1.11) 0.103
  AG 201 (35.6%) 169 (29.9%) 0.75 (0.58–0.96) 0.023
Dominant AA 336 (59.5%) 378 (66.8%) 1.00  
  GG + AG 229 (40.5%) 188 (33.2%) 0.73 (0.57–0.93) 0.011
Recessive AA + AG 537 (95%) 547 (96.6%) 1.00  
  GG 28 (5%) 19 (3.4%) 0.67 (0.37–1.21) 0.186
Additive /    0.76 (0.62–0.93) 0.009
rs13306435 Allele T 1089 (96.2%) 1094 (96.6%) 1.00  
  A 43 (3.8%) 38 (3.4%) 0.88 (0.56–1.37) 0.572
Codominant TT 524 (92.6%) 528 (93.3%) 1.00  
  AA 1 (0.2%) 0 (0%) / /
  AT 41 (7.2%) 38 (6.7%) 0.92 (0.58–1.45) 0.712
Dominant TT 524 (92.6%) 528 (93.3%) 1.00  
  AA + AT 42 (7.4%) 38 (6.7%) 0.90 (0.57–1.41) 0.634
Recessive TT + AT 565 (99.8%) 566 (100%) 1.00  
  AA 1 (0.2%) 0 (0%) / /
Additive /    0.88 (0.56–1.37) 0.560
  1. Bold indicates statistical signifcance (p < 0.05)
  2. SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval
  3. p values were calculated by logistic regression analysis adjusted age and sex