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Table 4 Relationship between IL-rs2069837 and ONFH susceptibility in different subgroups

From: An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

SNP Model Genotype Male Female
Case Control OR (95% CI) p Case Control OR (95% CI) p
Sex
 rs2069837 Allele A 514 475 1.00   411 398 1.00  
   G 114 145 0.73 (0.55–0.96) 0.023 93 112 0.80 (0.59–1.09) 0.164
  Codominant AA 210 115 1.00   168 156 1.00  
   GG 10 15 0.57 (0.25–1.31) 0.188 9 13 0.65 (0.27–1.55) 0.329
   AG 94 180 0.70 (0.50–0.98) 0.037 75 86 0.81 (0.56–1.19) 0.279
  Dominant AA 210 180 1.00   168 156 1.00  
   GG + AG 104 130 0.68 (0.49–0.95) 0.022 84 99 0.79 (0.55–1.14) 0.203
  Recessive AA + AG 304 295 1.00   243 242 1.00  
   GG 10 15 0.65 (0.29–1.47) 0.300 9 13 0.69 (0.29–1.65) 0.407
  Additive / / / 0.72 (0.54–0.95) 0.022 / / 0.81 (0.59–1.10) 0.173
SNP Model Genotype > 51 ≤ 51
Case Control OR (95% CI) p Case Control OR (95% CI) p
Age
 rs2069837 Allele A 506 449 1.00   419 424 1.00  
   G 108 139 0.69 (0.52–0.91) 0.009 99 118 0.85 (0.63–1.15) 0.284
  Codominant AA 206 169 1.00   175 167 1.00  
   GG 7 14 0.41 (0.16–1.05) 0.062 12 14 0.83 (0.37–1.85) 0.645
   AG 94 111 0.69 (0.49–0.98) 0.036 75 90 0.81 (0.56–1.17) 0.259
  Dominant AA 206 169 1.00   172 167 1.00  
   GG + AG 101 125 0.66 (0.48–0.92) 0.015 87 104 0.81 (0.57–1.16) 0.244
  Recessive AA + AG 300 280 1.00   247 257 1.00  
   GG 7 14 0.47 (0.19–1.18) 0.108 12 14 0.89 (0.40–1.960 0.770
  Additive / / / 0.68 (0.51–0.90) 0.008 / / 0.85 (0.64–1.14) 0.286
SNP Model Genotype Smoking Non-smoking
Case Control OR (95% CI) p Case Control OR (95% CI) p
Smoking
 rs2069837 Allele A 405 455 1.00   520 418 1.00  
   G 107 145 0.83 (0.6–1.10) 0.194 100 112 0.72 (0.53–0.97) 0.029
  Codominant AA 161 173 1.00   217 163 1.00  
   GG 12 18 0.69 (0.32–1.48) 0.343 7 10 0.54 (0.20–1.45) 0.220
   AG 83 109 0.82 (0.57–1.17) 0.278 86 92 0.69 (0.48–0.99) 0.046
  Dominant AA 161 173 1.00   217 163 1.00  
   GG + AG 95 127 0.80 (0.57–1.13) 0.205 93 102 0.68 (0.48–0.96) 0.029
  Recessive AA + AG 244 282 1.00   303 255 1.00  
   GG 12 18 0.74 (0.35–1.58) 0.438 7 10 0.60 (0.23–1.62) 0.317
  Additive / / / 0.83 (0.62–1.1) 0.182 / / 0.71 (0.52–0.96) 0.026
SNP Model Genotype Drinking Non-drinking
Case Control OR (95% CI) p Case Control OR (95% CI) p
Drinking
 rs2069837 Allele A 476 438 1.00   449 435 1.00  
   G 110 132 0.77 (0.58–1.02) 0.067 97 125 0.75 (0.56–1.01) 0.059
  Codominant AA 193 169 1.00   185 167 1.00  
   GG 10 16 0.53 (0.24–1.21) 0.133 9 12 0.68 (0.28–1.67) 0.401
   AG 90 100 0.79 (0.55–1.12) 0.182 79 101 0.69 (0.48–1.00) 0.048
  Dominant AA 193 169 1.00   185 167 1.00  
   GG + AG 100 116 0.75 (0.53–1.05) 0.098 88 113 0.69 (0.49–0.98) 0.040
  Recessive AA + AG 283 269 1.00   264 268 1.00  
   GG 10 16 0.58 (0.26–1.30) 0.187 9 12 0.77 (0.32–1.88) 0.569
  Additive / / / 0.76 (0.57–1.02) 0.063 / / 0.74 (0.55–1.00) 0.051
  1. Bold indicates statistical signifcance (p < 0.05)
  2. SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval
  3. p values were calculated by logistic regression analysis adjusted age and sex