Table 4 Relationship between IL-rs2069837 and ONFH susceptibility in different subgroups
From: An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development
SNP | Model | Genotype | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||
Sex | ||||||||||
rs2069837 | Allele | A | 514 | 475 | 1.00 | 411 | 398 | 1.00 | ||
G | 114 | 145 | 0.73 (0.55–0.96) | 0.023 | 93 | 112 | 0.80 (0.59–1.09) | 0.164 | ||
Codominant | AA | 210 | 115 | 1.00 | 168 | 156 | 1.00 | |||
GG | 10 | 15 | 0.57 (0.25–1.31) | 0.188 | 9 | 13 | 0.65 (0.27–1.55) | 0.329 | ||
AG | 94 | 180 | 0.70 (0.50–0.98) | 0.037 | 75 | 86 | 0.81 (0.56–1.19) | 0.279 | ||
Dominant | AA | 210 | 180 | 1.00 | 168 | 156 | 1.00 | |||
GG + AG | 104 | 130 | 0.68 (0.49–0.95) | 0.022 | 84 | 99 | 0.79 (0.55–1.14) | 0.203 | ||
Recessive | AA + AG | 304 | 295 | 1.00 | 243 | 242 | 1.00 | |||
GG | 10 | 15 | 0.65 (0.29–1.47) | 0.300 | 9 | 13 | 0.69 (0.29–1.65) | 0.407 | ||
Additive | / | / | / | 0.72 (0.54–0.95) | 0.022 | / | / | 0.81 (0.59–1.10) | 0.173 | |
SNP | Model | Genotype | > 51 | ≤ 51 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||
Age | ||||||||||
rs2069837 | Allele | A | 506 | 449 | 1.00 | 419 | 424 | 1.00 | ||
G | 108 | 139 | 0.69 (0.52–0.91) | 0.009 | 99 | 118 | 0.85 (0.63–1.15) | 0.284 | ||
Codominant | AA | 206 | 169 | 1.00 | 175 | 167 | 1.00 | |||
GG | 7 | 14 | 0.41 (0.16–1.05) | 0.062 | 12 | 14 | 0.83 (0.37–1.85) | 0.645 | ||
AG | 94 | 111 | 0.69 (0.49–0.98) | 0.036 | 75 | 90 | 0.81 (0.56–1.17) | 0.259 | ||
Dominant | AA | 206 | 169 | 1.00 | 172 | 167 | 1.00 | |||
GG + AG | 101 | 125 | 0.66 (0.48–0.92) | 0.015 | 87 | 104 | 0.81 (0.57–1.16) | 0.244 | ||
Recessive | AA + AG | 300 | 280 | 1.00 | 247 | 257 | 1.00 | |||
GG | 7 | 14 | 0.47 (0.19–1.18) | 0.108 | 12 | 14 | 0.89 (0.40–1.960 | 0.770 | ||
Additive | / | / | / | 0.68 (0.51–0.90) | 0.008 | / | / | 0.85 (0.64–1.14) | 0.286 | |
SNP | Model | Genotype | Smoking | Non-smoking | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||
Smoking | ||||||||||
rs2069837 | Allele | A | 405 | 455 | 1.00 | 520 | 418 | 1.00 | ||
G | 107 | 145 | 0.83 (0.6–1.10) | 0.194 | 100 | 112 | 0.72 (0.53–0.97) | 0.029 | ||
Codominant | AA | 161 | 173 | 1.00 | 217 | 163 | 1.00 | |||
GG | 12 | 18 | 0.69 (0.32–1.48) | 0.343 | 7 | 10 | 0.54 (0.20–1.45) | 0.220 | ||
AG | 83 | 109 | 0.82 (0.57–1.17) | 0.278 | 86 | 92 | 0.69 (0.48–0.99) | 0.046 | ||
Dominant | AA | 161 | 173 | 1.00 | 217 | 163 | 1.00 | |||
GG + AG | 95 | 127 | 0.80 (0.57–1.13) | 0.205 | 93 | 102 | 0.68 (0.48–0.96) | 0.029 | ||
Recessive | AA + AG | 244 | 282 | 1.00 | 303 | 255 | 1.00 | |||
GG | 12 | 18 | 0.74 (0.35–1.58) | 0.438 | 7 | 10 | 0.60 (0.23–1.62) | 0.317 | ||
Additive | / | / | / | 0.83 (0.62–1.1) | 0.182 | / | / | 0.71 (0.52–0.96) | 0.026 | |
SNP | Model | Genotype | Drinking | Non-drinking | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||||||||||||
Drinking | ||||||||||||||||||||
rs2069837 | Allele | A | 476 | 438 | 1.00 | 449 | 435 | 1.00 | ||||||||||||
G | 110 | 132 | 0.77 (0.58–1.02) | 0.067 | 97 | 125 | 0.75 (0.56–1.01) | 0.059 | ||||||||||||
Codominant | AA | 193 | 169 | 1.00 | 185 | 167 | 1.00 | |||||||||||||
GG | 10 | 16 | 0.53 (0.24–1.21) | 0.133 | 9 | 12 | 0.68 (0.28–1.67) | 0.401 | ||||||||||||
AG | 90 | 100 | 0.79 (0.55–1.12) | 0.182 | 79 | 101 | 0.69 (0.48–1.00) | 0.048 | ||||||||||||
Dominant | AA | 193 | 169 | 1.00 | 185 | 167 | 1.00 | |||||||||||||
GG + AG | 100 | 116 | 0.75 (0.53–1.05) | 0.098 | 88 | 113 | 0.69 (0.49–0.98) | 0.040 | ||||||||||||
Recessive | AA + AG | 283 | 269 | 1.00 | 264 | 268 | 1.00 | |||||||||||||
GG | 10 | 16 | 0.58 (0.26–1.30) | 0.187 | 9 | 12 | 0.77 (0.32–1.88) | 0.569 | ||||||||||||
Additive | / | / | / | 0.76 (0.57–1.02) | 0.063 | / | / | 0.74 (0.55–1.00) | 0.051 | |||||||||||