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Table 4 Distribution of associated haplotypes with risk of colorectal cancer

From: Association of SMAD7 genetic markers and haplotypes with colorectal cancer risk

Polymorphisms Haplotype Case Control p-value adj* OR (95%CI) adj.*
rs8085824-rs34007497 Others 289 (69.1%) 310 (77.5%) Ref  
T-C 129 (30.9%) 90 (22.5%) 0.029 1.55 (1.05–2.95)
rs8085824-rs4939827 Others 332 (79.4%) 362 (90.5%) Ref  
T-C 86 (20.6%) 38 (9.5%) 0.005 2.05 (1.24–3.42)
Others 368 (88.0%) 373 (93.2%) Ref  
C-T 50 (12.0%) 27 (6.8%) 0.001 2.67 (1.51–4.72)
Others 243 (58.1%) 173 (43.3%) Ref  
C-C 175 (41.9%) 227 (56.7%) 0.002 0.56 (0.40–0.80)
rs8088297-rs8085824-rs34007497 Others 292 (69.9%) 312 (78.0%) Ref  
A-T-C 126 (30.1%) 88 (22.0%) 0.047 1.49 (1.00–2.22)
rs8088297-rs8085824-rs4939827 Others 329 (78.7%) 364 (91.0%) Ref  
A-T-C 89 (21.3%) 36 (9.0%) 0.001 2.35 (1.42–3.89)
Others 369 (88.3%) 373 (93.2%) Ref  
A-C-T 49 (11.7%) 27 (6.8%) 0.002 2.52 (1.42–4.46)
Others 262 (62.7%) 198 (49.5%) Ref  
A-C-C 156 (37.3%) 202 (50.0%) 0.002 0.57 (0.40–0.82)
rs8085824-rs34007497-rs4939827 Others 357 (85.4%) 371 (92.7%) Ref  
T-C-C 61 (14.6%) 29 (7.3%) 0.002 2.38 (1.36–4.15)
Others 374 (89.5%) 374 (93.5%) Ref  
C-C-T 44 (10.5%) 26 (6.5%) 0.004 2.40 (1.33–4.35)
Others 269 (64.4%) 198 (49.5%) Ref  
C-C-C 149 (35.6%) 202 (50.5%) 0.001 0.54 (0.38–0.77)
rs4939827-rs34007497-rs8085824-rs8088297 Others 358 (85.6%) 373 (93.2%) Ref  
T-T-C-C 60 (14.4%) 27 (6.8%) 0.002 2.42 (1.37–4.27)
Others 374 (89.5%) 375 (93.8%) Ref  
T-C-C-A 44 (10.5%) 25 (6.2%) 0.001 2.63 (1.45–4.75)
Others 275 (65.8%) 221 (55.2%) Ref  
T-C-C-C 143 (34.2%) 179 (44.8%) 0.009 0.61 (0.43–0.88)
  1. All statistically significant P-values are shown in bold
  2. *Adjusted for age, sex and BMI