Table 4 Distribution of associated haplotypes with risk of colorectal cancer
From: Association of SMAD7 genetic markers and haplotypes with colorectal cancer risk
Polymorphisms | Haplotype | Case | Control | p-value adj* | OR (95%CI) adj.* |
|---|---|---|---|---|---|
rs8085824-rs34007497 | Others | 289 (69.1%) | 310 (77.5%) | Ref | |
T-C | 129 (30.9%) | 90 (22.5%) | 0.029 | 1.55 (1.05–2.95) | |
rs8085824-rs4939827 | Others | 332 (79.4%) | 362 (90.5%) | Ref | |
T-C | 86 (20.6%) | 38 (9.5%) | 0.005 | 2.05 (1.24–3.42) | |
Others | 368 (88.0%) | 373 (93.2%) | Ref | ||
C-T | 50 (12.0%) | 27 (6.8%) | 0.001 | 2.67 (1.51–4.72) | |
Others | 243 (58.1%) | 173 (43.3%) | Ref | ||
C-C | 175 (41.9%) | 227 (56.7%) | 0.002 | 0.56 (0.40–0.80) | |
rs8088297-rs8085824-rs34007497 | Others | 292 (69.9%) | 312 (78.0%) | Ref | |
A-T-C | 126 (30.1%) | 88 (22.0%) | 0.047 | 1.49 (1.00–2.22) | |
rs8088297-rs8085824-rs4939827 | Others | 329 (78.7%) | 364 (91.0%) | Ref | |
A-T-C | 89 (21.3%) | 36 (9.0%) | 0.001 | 2.35 (1.42–3.89) | |
Others | 369 (88.3%) | 373 (93.2%) | Ref | ||
A-C-T | 49 (11.7%) | 27 (6.8%) | 0.002 | 2.52 (1.42–4.46) | |
Others | 262 (62.7%) | 198 (49.5%) | Ref | ||
A-C-C | 156 (37.3%) | 202 (50.0%) | 0.002 | 0.57 (0.40–0.82) | |
rs8085824-rs34007497-rs4939827 | Others | 357 (85.4%) | 371 (92.7%) | Ref | |
T-C-C | 61 (14.6%) | 29 (7.3%) | 0.002 | 2.38 (1.36–4.15) | |
Others | 374 (89.5%) | 374 (93.5%) | Ref | ||
C-C-T | 44 (10.5%) | 26 (6.5%) | 0.004 | 2.40 (1.33–4.35) | |
Others | 269 (64.4%) | 198 (49.5%) | Ref | ||
C-C-C | 149 (35.6%) | 202 (50.5%) | 0.001 | 0.54 (0.38–0.77) | |
rs4939827-rs34007497-rs8085824-rs8088297 | Others | 358 (85.6%) | 373 (93.2%) | Ref | |
T-T-C-C | 60 (14.4%) | 27 (6.8%) | 0.002 | 2.42 (1.37–4.27) | |
Others | 374 (89.5%) | 375 (93.8%) | Ref | ||
T-C-C-A | 44 (10.5%) | 25 (6.2%) | 0.001 | 2.63 (1.45–4.75) | |
Others | 275 (65.8%) | 221 (55.2%) | Ref | ||
T-C-C-C | 143 (34.2%) | 179 (44.8%) | 0.009 | 0.61 (0.43–0.88) |