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Table 2  Result of the significant case–control association analysis between SNPs in the ADAM17 and asthma and allergies in KARE

From: Genetic polymorphism of ADAM17 and decreased bilirubin levels are associated with allergic march in the Korean population

Gene Chr No SNP BP Function A1 A2 Asthma Allergies
MAF OR (95% CI) Additive
p value
MAF OR (95% CI) Additive
p value
Case
(n = 193)
Control
(n = 3,228)
Case
(n = 528)
Control
(n = 3,228)
ADAM17 2 1 rs17524376 9,542,245 Intronic A T 0.042 0.025 1.79 (1.06–3.03) 0.0293 0.032 0.024 1.30 (0.88–1.91) 4
2 rs6432011 9,542,900 Intronic C T 0.091 0.050 1.95 (1.35–2.82) 0.0004 0.067 0.050 1.35 (1.03–1.78) 0.0291
3 rs4319913 9,543,433 Intronic T C 0.091 0.050 1.95 (1.35–2.82) 0.0004 0.067 0.050 1.35 (1.03–1.78) 0.0291
4 rs17524425 9,543,455 Intronic C T 0.041 0.025 1.76 (1.05–2.95) 0.0334 0.031 0.024 1.27 (0.86–1.87) 0.2148
5 rs4622692 9,550,588 3_UTR C A 0.091 0.051 1.92 (1.33–2.77) 0.0005 0.067 0.050 1.34 (1.02–1.75) 0.0353
6 rs11690126 9,556,772 Intronic A C 0.049 0.025 2.01 (1.23–3.30) 0.0057 0.035 0.025 1.42 (0.97–2.06) 0.0673
7 rs34367192 9,559,929 3_UTR A G 0.041 0.025 1.78 (1.05–3.02) 0.0310 0.031 0.024 1.26 (0.85–1.86) 0.2341
8 rs2276338 9,563,240 Intronic T C 0.091 0.050 1.94 (1.34–2.81) 0.0004 0.067 0.050 1.35 (1.02–1.77) 0.0314
9 rs7580419 9,563,839 3_UTR A G 0.091 0.050 1.95 (1.34–2.82) 0.0004 0.067 0.050 1.35 (1.02–1.78) 0.0303
10 rs10495563 9,579,661 5_UTR T C 0.091 0.050 1.94 (1.34–2.82) 0.0004 0.067 0.050 1.35 (1.02–1.78) 0.0304
11 rs10929587 9,580,271 Intronic A T 0.089 0.049 1.93 (1.33–2.81) 0.0005 0.067 0.048 1.38 (1.05–1.82) 0.0192
12 rs10179642 9,601,147 5_UTR G A 0.049 0.025 2.02 (1.23–3.32) 0.0055 0.036 0.025 1.46 (1.01–2.13) 0.0428
13 rs11684747 9,614,622 5_UTR C T 0.041 0.025 1.78 (1.06–3.00) 0.0302 0.031 0.0247 1.27 (0.86–1.87) 0.2164
  1. P-values lower than the significance level (P < 0.05) are indicated in bold
  2. Chr, chromosome; No, number; BP, base pair; A1, minor allele; A2, major allele; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval. The SNP positions were based on NCBI Build 36 human genome assembly. Age, sex, and residential area were included as covariates in additive genetic models. P-values lower than the significance level (p < 0.05) are indicated in bold and underlined