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Table 2  Result of the significant case–control association analysis between SNPs in the ADAM17 and asthma and allergies in KARE

From: Genetic polymorphism of ADAM17 and decreased bilirubin levels are associated with allergic march in the Korean population

Gene

Chr

No

SNP

BP

Function

A1

A2

Asthma

Allergies

MAF

OR (95% CI)

Additive

p value

MAF

OR (95% CI)

Additive

p value

Case

(n = 193)

Control

(n = 3,228)

Case

(n = 528)

Control

(n = 3,228)

ADAM17

2

1

rs17524376

9,542,245

Intronic

A

T

0.042

0.025

1.79 (1.06–3.03)

0.0293

0.032

0.024

1.30 (0.88–1.91)

4

2

rs6432011

9,542,900

Intronic

C

T

0.091

0.050

1.95 (1.35–2.82)

0.0004

0.067

0.050

1.35 (1.03–1.78)

0.0291

3

rs4319913

9,543,433

Intronic

T

C

0.091

0.050

1.95 (1.35–2.82)

0.0004

0.067

0.050

1.35 (1.03–1.78)

0.0291

4

rs17524425

9,543,455

Intronic

C

T

0.041

0.025

1.76 (1.05–2.95)

0.0334

0.031

0.024

1.27 (0.86–1.87)

0.2148

5

rs4622692

9,550,588

3_UTR

C

A

0.091

0.051

1.92 (1.33–2.77)

0.0005

0.067

0.050

1.34 (1.02–1.75)

0.0353

6

rs11690126

9,556,772

Intronic

A

C

0.049

0.025

2.01 (1.23–3.30)

0.0057

0.035

0.025

1.42 (0.97–2.06)

0.0673

7

rs34367192

9,559,929

3_UTR

A

G

0.041

0.025

1.78 (1.05–3.02)

0.0310

0.031

0.024

1.26 (0.85–1.86)

0.2341

8

rs2276338

9,563,240

Intronic

T

C

0.091

0.050

1.94 (1.34–2.81)

0.0004

0.067

0.050

1.35 (1.02–1.77)

0.0314

9

rs7580419

9,563,839

3_UTR

A

G

0.091

0.050

1.95 (1.34–2.82)

0.0004

0.067

0.050

1.35 (1.02–1.78)

0.0303

10

rs10495563

9,579,661

5_UTR

T

C

0.091

0.050

1.94 (1.34–2.82)

0.0004

0.067

0.050

1.35 (1.02–1.78)

0.0304

11

rs10929587

9,580,271

Intronic

A

T

0.089

0.049

1.93 (1.33–2.81)

0.0005

0.067

0.048

1.38 (1.05–1.82)

0.0192

12

rs10179642

9,601,147

5_UTR

G

A

0.049

0.025

2.02 (1.23–3.32)

0.0055

0.036

0.025

1.46 (1.01–2.13)

0.0428

13

rs11684747

9,614,622

5_UTR

C

T

0.041

0.025

1.78 (1.06–3.00)

0.0302

0.031

0.0247

1.27 (0.86–1.87)

0.2164

  1. P-values lower than the significance level (P < 0.05) are indicated in bold
  2. Chr, chromosome; No, number; BP, base pair; A1, minor allele; A2, major allele; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval. The SNP positions were based on NCBI Build 36 human genome assembly. Age, sex, and residential area were included as covariates in additive genetic models. P-values lower than the significance level (p < 0.05) are indicated in bold and underlined
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BMC Medical Genomics

ISSN: 1755-8794

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