Table 4 ADRs of patients with CYP2C8 (rs1058932), CYP2C8 (rs10882526), and CYP3A5 (rs776746)
ADR | Gene | SNP | Genotype | Normal group (n) | Abnormal group (n) | P | 95% CI |
|---|---|---|---|---|---|---|---|
Renal function | CYP2C8 | rs1058932 | AA | 22 | 1 | 0.017 | 0.014–0.019 |
AG | 43 | 14 | |||||
GG | 60 | 6 | |||||
Ophthalmic | CYP2C8 | rs10882526 | GG | 1 | 2 | 0.026 | 0.006–0.835 |
AA | 97 | 14 | |||||
AG | 28 | 4 | |||||
Skin and mucous membrane | CYP3A5 | rs776746 | CT | 50 | 5 | 0.033 | 0.038–0.046 |
TT | 5 | 3 | |||||
CC | 36 | 7 |