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Table 4 ADRs of patients with CYP2C8 (rs1058932), CYP2C8 (rs10882526), and CYP3A5 (rs776746)

From: Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions

ADR Gene SNP Genotype Normal group (n) Abnormal group (n) P 95% CI
Renal function CYP2C8 rs1058932 AA 22 1 0.017 0.014–0.019
AG 43 14
GG 60 6
Ophthalmic CYP2C8 rs10882526 GG 1 2 0.026 0.006–0.835
AA 97 14
  AG 28 4
Skin and mucous membrane CYP3A5 rs776746 CT 50 5 0.033 0.038–0.046
TT 5 3
CC 36 7