Table 3 Details of the base mutation and amino acid changes in exon 5 in the novel allele HLA-A*11:335 in comparison to HLA-A*11:01:01:01
Base position | 899 | 900 | 916 | 934 | 951 | 956 | 964 | 987 | 990 | 1001 |
|---|---|---|---|---|---|---|---|---|---|---|
A*11:01:01:01 | T | G | A | A | C | G | A | C | G | G |
A*11:335 | C | A | G | G | A | T | G | T | A | A |
Codon change | CTG > CCA | ATC > GTC | ATT > GTT | CTC > CTA | GGA > GTA | ATC > GTC | GCC > GCT | GTG > GTA | AGG > AAG | |
AA. substitution | Leu > Pro | Ile > Val | Ile > Val | Leu = Leu | Gly > Val | Ile > Val | Ala = Ala | Val = Val | Arg > Lys | |
Codon position | 276 | 282 | 288 | 293 | 295 | 298 | 305 | 306 | 310 | |