Fig. 4

Genomic analysis. a Non-synonymous, pathogenic, somatic variants of the primary ovarian tumor. b Mapping of the variant allele frequency (VAF) of each SNP using TOP DNA panel in the normal (upper panel) and primary ovarian tumor (lower panel). Arrow: A/B hetero SNPs. c Distribution of the VAF of each SNP in the primary ovarian tumor and a paired normal sample. d Droplet digital PCR (ddPCR) of KRAS pathogenic variant, using the primary ovarian tumor, peritoneal dissemination at the initial recurrence, and appendix obtained from autopsy