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Table 3 Genotype and allele frequencies of the studied polymorphisms in patients and healthy control

From: Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population

Gene (polymorphism) Inheritance models Genotype and Allele Case (%) Control (%) p Value OR (95% CI)
CATSPER1 (rs2845570) Codominant GG 81 (81%) 98 (98%) Ref Ref = 1
GT 14 (14%) 2 (2%) 0.001* 8.47 (2.14–38.1)
TT 5 (5%) 0 (0%) 0.021* Infinity (1.7–infinity)
Dominant GG 81 (81%) 98 (98%) Ref Ref = 1
GT + GG 19 (19%) 2 (2%) 0.0001* 11.49 (2.8–50.7)
Recessive TT 5 (5%) 0 (0%) Ref Ref = 1
GT + GG 95 (95%) 100 (100%) 0.059 Infinity (1.5–infinity)
Overdominant GT 14 (14%) 2 (2%) Ref Ref = 1
GG + TT 86 (86%) 98 (98%) 0.0029* 7.97 (2.02–35.8)
Alleles G wild 176 (88%) 198 (99%) Ref Ref = 1
T mutant 24 (12%) 2 (1%) 0.0001* 13.5 (3.6–58.4)
SPATA16 (rs1515442) Codominant TT 87 (87%) 96 (96%) Ref Ref = 1
TC 12 (12%) 4 (4%) 0.039* 3.31 (1.01–9.61)
CC 1 (1%) 0 (0%) 0.478 Infinity (0.12–infinity)
Dominant TT 87 (87%) 96 (96%) Ref Ref = 1
TC + CC 13 (13%) 4 (4%) 0.039* 3.58 (1.14–10.3)
Recessive CC 1 (1%) 0 (1%) Ref Ref = 1
TC + TT 99 (99%) 100 (100%)  > 0.999 Infinity (0.11–infinity)
Overdominant TC 12 (12%) 4 (4%) Ref Ref = 1
CC + TT 88 (88%) 96 (96%) 0.065 3.27 (1.0–9.5)
Alleles T wild 186 (93%) 196 (98%) Ref Ref = 1
C mutant 14 (7%) 4 (2%) 0.016* 3.69 (1.2–10.4)
TEX11 (rs143246552) Codominant TT 95 (95%) 98 (98%) Ref Ref = 1
TC 2 (2%) 2 (2%) 0.999 1.03 (0.815–6.7)
CC 3 (3%) 0 (0%) 0.246 Infinity (0.87–infinity)
Dominant TT 95 (95%) 98 (98%) Ref Ref = 1
TC + CC 5 (5%) 2 (2%) 0.444 2.58 (0.53–13.1)
Recessive CC 3 (3%) 0 (0%) Ref Ref = 1
TC + TT 97 (97%) 100 (100%) 0.246 Infinity (0.87–infinity)
Overdominant TC 2 (2%) 2 (2%) Ref Ref = 1
CC + TT 98 (98%) 98 (98%) 1 1 (0.15–6.48)
Alleles T wild 192 (96%) 198 (99%) Ref Ref = 1
C mutant 8 (4%) 2 (1%) 0.055 4.12 (1.0–19.4)
  1. *Statistically Significant p < 0.05
  2. OR odds ratio, CI confidence interval