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Table 4 Centrality: Node(s) of maximum degree in the epistatic network obtained by joining the physical epistatic network and the eQTL epistatic network

From: A systematic analysis of gene–gene interaction in multiple sclerosis

Map ID Max node degree p-value Node(s) of max degree
3302 4 0.033 ADAM17, CNTN1 (F3)
3305 2 0.365 SUFU
3306 6 0.000 GSK3 beta
4455 11 0.000 WASF2
4593 4 0.086 NCX1
4693 10 0.000 mTORC1
4703 5 0.056 AKT(PKB), Caspase-8
4791 5 0.018 AKT(PKB), PI3K reg class IA
4794 2 0.553 DHA2, GALC
4843 8 0.000 SHP-2
4846 11 0.000 Neuregulin 1
4901 12 0.000 FAK1
5199 7 0.001 JAK2
5288 6 0.001 IL-1RI, ROR-alpha
5378 5 0.013 JNK(MAPK8-10)
5398 6 0.001 TRADD
5518 6 0.004 AKT(PKB)
5601 7 0.000 Bcl-XL
5611 5 0.018 Granzyme B, KLRK1 (NKG2D)
  1. The bold values correspond to p-values below the significance threshold of 0.05