Table 4 Centrality: Node(s) of maximum degree in the epistatic network obtained by joining the physical epistatic network and the eQTL epistatic network
From: A systematic analysis of gene–gene interaction in multiple sclerosis
Map ID | Max node degree | p-value | Node(s) of max degree |
|---|---|---|---|
3302 | 4 | 0.033 | ADAM17, CNTN1 (F3) |
3305 | 2 | 0.365 | SUFU |
3306 | 6 | 0.000 | GSK3 beta |
4455 | 11 | 0.000 | WASF2 |
4593 | 4 | 0.086 | NCX1 |
4693 | 10 | 0.000 | mTORC1 |
4703 | 5 | 0.056 | AKT(PKB), Caspase-8 |
4791 | 5 | 0.018 | AKT(PKB), PI3K reg class IA |
4794 | 2 | 0.553 | DHA2, GALC |
4843 | 8 | 0.000 | SHP-2 |
4846 | 11 | 0.000 | Neuregulin 1 |
4901 | 12 | 0.000 | FAK1 |
5199 | 7 | 0.001 | JAK2 |
5288 | 6 | 0.001 | IL-1RI, ROR-alpha |
5378 | 5 | 0.013 | JNK(MAPK8-10) |
5398 | 6 | 0.001 | TRADD |
5518 | 6 | 0.004 | AKT(PKB) |
5601 | 7 | 0.000 | Bcl-XL |
5611 | 5 | 0.018 | Granzyme B, KLRK1 (NKG2D) |