Fig. 3

CNV heterogeneity at single cell level. A CNV profiles. Each row corresponds to a cell. The cells are labeled with regard to source tissue, clone annotation, HBV integration category and HBV sequence detection result. Each column corresponds to a bin. The bins are ordered by their chromosome locations (chromosome 1–22). Cells can be categorized into 4 groups corresponding to 4 clones. White means normal copy number, blue indicates copy number loss, red indicates copy number amplification. B Composition of cells with no HBV detected, cells with HBV sequence detected but no integration, cells carrying rare integration, and cells carrying only hotspot integration only in each clone. The frequency of cells carrying rare HBV integrations is highest for clone 1 and lowest for clone 4. The frequencies for clones 2 and 3 were comparable, and both were lower than the one for clone 1