Table 1 Number of affected families due to reclassified variants
Re-classification | Involved variants | Involved probands |
|---|---|---|
Increased risk (VUS → Pathogenic/Likely pathogenic) | 13 (5.5%) | 31 (6.8%) |
Downgrade of risk (VUS → Likely Benign) | 8 (3.4%) | 69 (15.0%) |
Back to potential risk (Likely Benign → VUS) | 5 (2.1%) | 46 (10.0%) |
Remain no change (VUS → VUS) | 210 (89.0%) | 313 (68.2%) |