Fig. 2
Dynamic imaging of lung lesions at different stages of Crizotinib treatment. A The baseline of diagnosis (before treatment): Chest computed tomography scan revealed a mass in the right middle and lower lobe (3.6*3.4Â cm), and enlarged lymph nodes in the right hilum and mediastinum; B The first evaluation after one cycle of chemotherapy showed progressed of disease with enlarging lymph nodes in the right hilum and mediastinum; C The second evaluation after 1Â month of Crizotinib therapy showed partial remission according to RECIST1.1 criteria; D and E Evaluation after approximately 6Â months of Crizotinib treatment showed progressive disease of lung lesion and metastasis in right pleura and brain. The measuring scale of all CT image is 20Â cm (equipment: GE optima 2), and the MRI is 10Â cm (equipment: Philips multiva 1.5Â T)