Table 3 Genetic models analysis of associations between the genotypes of FKBP5 rs1360780 and rs3800373 with PCOS
SNPs | Model | Genotype | PCOS | Control | OR (95% CI) | p-value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
rs1360780 | Co-dominant | C/C | 425 (54.2%) | 432 (55.2%) | 1 | 0.03 | 2717 | 2187 |
|  |  | C/T | 324 (41.3%) | 293 (37.4%) | 0.89 (0.72–1.09) |  |  |  |
|  |  | T/T | 35 (4.5%) | 58 (7.4%) | 1.63 (1.05–2.53) |  |  |  |
| Â | Dominant | C/C | 425 (54.2%) | 432 (55.2%) | 1 | 0.70 | 2176.2 | 2186.9 |
|  |  | C/T-T/T | 359 (45.8%) | 351 (44.8%) | 0.96 (0.79–1.17) |  |  |  |
|  | Recessive | C/C–C/T | 749 (95.5%) | 725 (92.6%) | 1 | 0.01 | 2170.2 | 2180.9 |
|  |  | T/T | 35 (4.5%) | 58 (7.4%) | 1.71 (1.11–2.64) |  |  |  |
| Â | Overdominant | C/C-T/T | 460 (58.7%) | 490 (62.6%) | 1 | 0.11 | 2173.8 | 2184.5 |
|  |  | C/T | 324 (41.3%) | 293 (37.4%) | 0.85 (0.69–1.04) |  |  |  |
|  | Log-additive | – | – | – | 1.06 (0.90–1.24) | 0.52 | 2175.9 | 2186.6 |
rs3800373 | Co-dominant | A/A | 430 (55%) | 432 (56%) | 1 | 0.03 | 2151.8 | 2167.8 |
|  |  | C/A | 315 (40.3%) | 280 (36.3%) | 0.88 (0.70–1.10) |  |  |  |
|  |  | C/C | 37 (4.7%) | 59 (7.7%) | 1.59 (1.03–2.45) |  |  |  |
| Â | Dominant | A/A | 430 (55%) | 432 (56%) | 1 | 0.68 | 2156.7 | 2167.8 |
|  |  | C/A-C/C | 352 (45%) | 339 (44%) | 0.96 (0.78–1.17) |  |  |  |
| Â | Recessive | A/A-C/A | 745 (95.3%) | 712 (92.3%) | 1 | 0.02 | 2151.1 | 2161.8 |
|  |  | C/C | 37 (4.7%) | 59 (7.7%) | 1.67 (1.09–2.55) |  |  |  |
| Â | Overdominant | A/A-C/C | 467 (59.7%) | 491 (63.7%) | 1 | 0.11 | 2154.3 | 2164.9 |
|  |  | C/A | 315 (40.3%) | 280 (36.3%) | 0.85 (0.69–1.04) |  |  |  |
|  | Log-additive | – | – | – | 1.05 (0.89–1.24) | 0.55 | 2156.5 | 2167.2 |