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Table 4 Genotype frequencies and genetic model analysis of FKBP5 SNPs in the HA PCOS patients group and the NHA PCOS patients group

From: Association of SNPs in the FK-506 binding protein (FKBP5) gene among Han Chinese women with polycystic ovary syndrome

SNPs

Model

Genotype

HA

NHA

OR (95% CI)

p-value

AIC

BIC

rs1360780

Codominant

C/C

328 (55.8%)

91 (48.7%)

1

0.09

857.7

871.6

  

C/T

238 (40.5%)

83 (44.4%)

1.26 (0.89–1.77)

   
  

T/T

22 (3.7%)

13 (7%)

2.13 (1.03–4.39)

   
 

Dominant

C/C

328 (55.8%)

91 (48.7%)

1

0.09

857.6

866.9

  

C/T-T/T

260 (44.2%)

96 (51.3%)

1.33 (0.96–1.85)

   
 

Recessive

C/C–C/T

566 (96.3%)

174 (93%)

1

0.08

857.4

866.7

  

T/T

22 (3.7%)

13 (7%)

1.92 (0.95–3.90)

   
 

Overdominant

C/C-T/T

350 (59.5%)

104 (55.6%)

1

0.35

859.6

868.9

  

C/T

238 (40.5%)

83 (44.4%)

1.17 (0.84–1.64)

   
 

Log-additive

–

–

–

1.35 (1.02–1.77)

0.04

856.1

865.4

rs9470080

Codominant

C/C

268 (45.7%)

71 (38%)

1

0.09

856.5

870.5

  

T/C

270 (46.1%)

93 (49.7%)

1.30 (0.91–1.85)

   
  

T/T

48 (8.2%)

23 (12.3%)

1.81 (1.03–3.17)

   
 

Dominant

C/C

268 (45.7%)

71 (38%)

1

0.06

855.9

865.2

  

T/C-T/T

318 (54.3%)

116 (62%)

1.38 (0.98–1.93)

   
 

Recessive

C/C-T/C

538 (91.8%)

164 (87.7%)

1

0.10

856.7

866

  

T/T

48 (8.2%)

23 (12.3%)

1.57 (0.93–2.66)

   
 

Overdominant

C/C-T/T

316 (53.9%)

94 (50.3%)

1

0.38

858.6

867.9

  

T/C

270 (46.1%)

93 (49.7%)

1.16 (0.83–1.61)

   
 

Log-additive

–

–

–

1.33 (1.03–1.71)

0.03

854.5

863.8

rs9296158

Codominant

G/G

276 (47%)

72 (38.5%)

1

0.09

857.2

871.1

  

G/A

266 (45.3%)

95 (50.8%)

1.37 (0.97–1.94)

   
  

A/A

45 (7.7%)

20 (10.7%)

1.70 (0.95–3.06)

   
 

Dominant

G/G

276 (47%)

72 (38.5%)

1

0.04

855.7

865

  

G/A-A/A

311 (53%)

115 (61.5%)

1.42 (1.01–1.98)

   
 

Recessive

G/G-G/A

542 (92.3%)

167 (89.3%)

1

0.20

858.3

867.6

  

A/A

45 (7.7%)

20 (10.7%)

1.44 (0.83–2.51)

   
 

Overdominant

G/G-A/A

321 (54.7%)

92 (49.2%)

1

0.19

858.2

867.5

  

G/A

266 (45.3%)

95 (50.8%)

1.25 (0.90–1.73)

   
 

Log-additive

–

–

–

1.33 (1.03–1.72)

0.03

855.2

864.6

rs1043805

Codominant

A/A

398 (67.9%)

116 (62%)

1

0.03

854.5

868.5

  

T/A

174 (29.7%)

59 (31.6%)

1.16 (0.81–1.67)

   
  

T/T

14 (2.4%)

12 (6.4%)

2.94 (1.32–6.53)

   
 

Dominant

A/A

398 (67.9%)

116 (62%)

1

0.14

857.2

866.5

  

T/A-T/T

188 (32.1%)

71 (38%)

1.30 (0.92–1.83)

   
 

Recessive

A/A-T/A

572 (97.6%)

175 (93.6%)

1

0.01

853.2

862.5

  

T/T

14 (2.4%)

12 (6.4%)

2.80 (1.27–6.17)

   
 

Overdominant

A/A-T/T

412 (70.3%)

128 (68.5%)

1

0.63

859.1

868.4

  

T/A

174 (29.7%)

59 (31.6%)

1.09 (0.76–1.56)

   
 

Log-additive

–

–

–

1.37 (1.03–1.83)

0.03

854.9

864.2

rs7757037

Codominant

A/A

225 (38.3%)

56 (29.9%)

1

0.07

856.7

870.6

  

G/A

285 (48.5%)

98 (52.4%)

1.38 (0.95–2.00)

   
  

G/G

77 (13.1%)

33 (17.6%)

1.72 (1.04–2.84)

   
 

Dominant

A/A

225 (38.3%)

56 (29.9%)

1

0.04

855.5

864.8

  

G/A-G/G

362 (61.7%)

131 (70%)

1.45 (1.02–2.07)

   
 

Recessive

A/A-G/A

510 (86.9%)

154 (82.3%)

1

0.13

857.6

866.9

  

G/G

77 (13.1%)

33 (17.6%)

1.42 (0.91–2.22)

   
 

Overdominant

A/A-G/G

302 (51.5%)

89 (47.6%)

1

0.36

859.1

868.4

  

G/A

285 (48.5%)

98 (52.4%)

1.17 (0.84–1.62)

   
 

Log-additive

–

–

–

1.32 (1.04–1.69)

0.02

854.8

864.1

  1. OR and 95% CI in bold indicates statistical significance
  2. HA hyperandrogenemia, NHA non-hyperandrogenemia, OR odds ratio, AIC Akaike Information Criterion. BIC Bayesian information criterion
  3. The association between each SNP and the susceptibility to HA was evaluated by calculating the odds ratio (OR) with their 95% confidence interval (95% CI) with a logistic regression analysis under five genetic models (the co-dominant model, the dominant model, the recessive model, the overdominant model and the log-additive model)
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BMC Medical Genomics

ISSN: 1755-8794

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