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Table 3 Top 10 skin proteins with significant up-regulation in chemical warfare victims

From: Proteomics analysis of chronic skin injuries caused by mustard gas

Accession ID P-value Fold change Gene name Protein name Pathogenesis pathway
P82932 1.8E−04 1.79 MRPS6 28S ribosomal protein S6, mitochondrial OS = Homo sapiens OX = 9606 GN = MRPS6 PE = 1 SV = 3 Disorder of oxidative phosphorylation process and disruption of mitochondrial protein synthesis, Decreased cell survival, impaired glycolic metabolism, and many biological activities
P05161 1.0E−02 1.62 ISG15 Ubiquitin-like protein ISG15 OS = Homo sapiens OX = 9606 GN = ISG15 PE = 1 SV = 5 Dysfunction of intracellular proteins and immune responses
Q9UDW1 1.9E−06 1.60 UQCR10 Cytochrome b-c1 complex subunit 9 OS = Homo sapiens OX = 9606 GN = UQCR10 PE = 1 SV = 3 Cell death and apoptosis, Production of reactive oxygen species (ROS)
Q969E8 2.5E−02 1.58 TSR2 Pre-rRNA-processing protein TSR2 homolog OS = Homo sapiens OX = 9606 GN = TSR2 PE = 1 SV = 1 Inhibition of NF-κB transcriptional activity and disruption of the apoptotic process
K7ELC2 7.4E−03 1.54 RPS15 40S ribosomal protein S15 OS = Homo sapiens OX = 9606 GN = RPS15 PE = 1 SV = 1 Loss of cell nucleus integrity and irregularities in cell growth and proliferation
P09669 1.8E−02 1.50 COX6C Cytochrome c oxidase subunit 6C OS = Homo sapiens OX = 9606 GN = COX6C PE = 1 SV = 2 Irregularities in the process of apoptosis and oxidative phosphorylation of tissue cells
O95715 4.3E−03 1.49 CXCL14 C-X-C motif chemokine 14 OS = Homo sapiens OX = 9606 GN = CXCL14 PE = 1 SV = 2 Disruption of cell migration, impaired regulation of immune activity, especially anti-bacterial immunity, impaired use of CD14 + DC precursors and inflammation
P16403 3.5E−02 1.47 H1-2 Histone H1.2 OS = Homo sapiens OX = 9606 GN = HIST1H1C PE = 1 SV = 2 Disorders of cell cycle regulation, induction of apoptosis, the release of cytochrome C from mitochondria, and caspase-dependent cell death
Q99572 3.6E−02 1.46 P2RX7 P2X purinoceptor 7 OS = Homo sapiens OX = 9606 GN = P2RX7 PE = 1 SV = 4 Degradation of differentiated keratinocytes, release of pro-inflammatory mediators, proliferation of tumor cells, formation of reactive oxygen and nitrogen species
O14908 2.8E−03 1.45 GIPC1 PDZ domain-containing protein GIPC1 OS = Homo sapiens OX = 9606 GN = GIPC1 PE = 1 SV = 2 Impaired proliferation, cell surface polarity, cytokinesis and cell migration