Table 3 Top 10 skin proteins with significant up-regulation in chemical warfare victims
From: Proteomics analysis of chronic skin injuries caused by mustard gas
Accession ID | P-value | Fold change | Gene name | Protein name | Pathogenesis pathway |
|---|---|---|---|---|---|
P82932 | 1.8E−04 | 1.79 | MRPS6 | 28S ribosomal protein S6, mitochondrial OS = Homo sapiens OX = 9606 GN = MRPS6 PE = 1 SV = 3 | Disorder of oxidative phosphorylation process and disruption of mitochondrial protein synthesis, Decreased cell survival, impaired glycolic metabolism, and many biological activities |
P05161 | 1.0E−02 | 1.62 | ISG15 | Ubiquitin-like protein ISG15 OS = Homo sapiens OX = 9606 GN = ISG15 PE = 1 SV = 5 | Dysfunction of intracellular proteins and immune responses |
Q9UDW1 | 1.9E−06 | 1.60 | UQCR10 | Cytochrome b-c1 complex subunit 9 OS = Homo sapiens OX = 9606 GN = UQCR10 PE = 1 SV = 3 | Cell death and apoptosis, Production of reactive oxygen species (ROS) |
Q969E8 | 2.5E−02 | 1.58 | TSR2 | Pre-rRNA-processing protein TSR2 homolog OS = Homo sapiens OX = 9606 GN = TSR2 PE = 1 SV = 1 | Inhibition of NF-κB transcriptional activity and disruption of the apoptotic process |
K7ELC2 | 7.4E−03 | 1.54 | RPS15 | 40S ribosomal protein S15 OS = Homo sapiens OX = 9606 GN = RPS15 PE = 1 SV = 1 | Loss of cell nucleus integrity and irregularities in cell growth and proliferation |
P09669 | 1.8E−02 | 1.50 | COX6C | Cytochrome c oxidase subunit 6C OS = Homo sapiens OX = 9606 GN = COX6C PE = 1 SV = 2 | Irregularities in the process of apoptosis and oxidative phosphorylation of tissue cells |
O95715 | 4.3E−03 | 1.49 | CXCL14 | C-X-C motif chemokine 14 OS = Homo sapiens OX = 9606 GN = CXCL14 PE = 1 SV = 2 | Disruption of cell migration, impaired regulation of immune activity, especially anti-bacterial immunity, impaired use of CD14 + DC precursors and inflammation |
P16403 | 3.5E−02 | 1.47 | H1-2 | Histone H1.2 OS = Homo sapiens OX = 9606 GN = HIST1H1C PE = 1 SV = 2 | Disorders of cell cycle regulation, induction of apoptosis, the release of cytochrome C from mitochondria, and caspase-dependent cell death |
Q99572 | 3.6E−02 | 1.46 | P2RX7 | P2X purinoceptor 7 OS = Homo sapiens OX = 9606 GN = P2RX7 PE = 1 SV = 4 | Degradation of differentiated keratinocytes, release of pro-inflammatory mediators, proliferation of tumor cells, formation of reactive oxygen and nitrogen species |
O14908 | 2.8E−03 | 1.45 | GIPC1 | PDZ domain-containing protein GIPC1 OS = Homo sapiens OX = 9606 GN = GIPC1 PE = 1 SV = 2 | Impaired proliferation, cell surface polarity, cytokinesis and cell migration |