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Table 5 Phenotype PRS percentiles for each family individual

From: Implementation of individualised polygenic risk score analysis: a test case of a family of four

Phenotype

PT00007A (Father)

PT00008A (Mother)

PT00009A (Daughter)

PT00002A (Son)

Colorectal Cancer

97.42

79.92

97.22

91.05

Coronary artery disease

29.62

96.62

89.86

81.91

Testicular cancer

42.35

90.66

95.83

38.37

Glaucoma

88.67

42.35

65.01

65.21

Type 2 diabetes

60.44

71.37

68.79

45.33

Prostate cancer

50.50

80.91

92.45

21.67

Thyroid cancer

49.30

50.50

32.41

90.66

Breast cancer

17.30

85.69

53.28

64.61

Ischaemic stroke

26.24

82.90

64.02

38.17

Inflammatory bowel disease

43.54

70.78

46.72

46.72

Chronic lymph leukaemia

16.50

45.53

41.15

44.14

Basal cell carcinoma

55.86

7.55

10.54

14.12

Glioma

4.57

42.35

18.69

5.96

Melanoma

14.51

9.74

22.86

23.26

Atrial fibrillation

16.50

15.51

8.55

7.16

  1. Bold font highlights percentiles below 20 and above 80. Italicised bold font indicates percentiles in the top and bottom 5th risk percentile. Phenotypes in the table have been ordered to highlight patterns