Fig. 2From: RASopathies due to de novo pathogenic variants: clinical features, genetic findings and outcomes in nine neonates born with congenital heart defectsDetailed analysis of the novel missense variant (NM_002890.2: c.2828 T > C, p.Leu943Pro) in RASA1 gene. a Pathogenicity analyses by PolyPhen-2. b In silico analysis in different species by T-Coffee Multiple Sequence Alignment Program. c 3D structure models of wild type and mutant type in RASA1 by HOPEBack to article page