Genetic liability to obesity and peptic ulcer disease: a Mendelian randomization study

BMC Medical Genomics

Table 1 Detailed information on data sources

Phenotype	Study or consortium	Ancestry	Sample size	Cases	Adjustment
PUD	UKBiobank	European	456,327	16,666	Sex, age and 20 ancestry principal components
BMI	UKBiobank + GIANT	European	806,834	–	Age, age-squared, sex and principal components 1–5
WHR	UKBiobank + GIANT	European	697,734	–	Age, age-squared, sex and principal components 1–5
H.P. infection	UKBiobank	European	462,933	1,329	Age, sex, 10 genetic principal components, and genotyping batch
T2D	DIAGRAM	European	149,821	34,840	Study-specific covariates, including indicators of population structure
LDL-C, HDL-C, TC, TG	GLGC	European	188,578	–	Age, age², and sex
Smoking, alcohol use	GSCAN	European	1,232,091	–	Age, sex, age × sex interaction, and the first ten genetic principle components
BMI	GIANT	European	339,224	–	Age, age squared, and any necessary study-specific covariates (e.g. genotype-derived principal components)
WHR	GIANT	European	224,459	–	Age, age², and other study-specific covariates

PUD peptic ulcer disease; BMI body mass index; WHR waist-to-hip ratio; H.P. Helicobacter Pylori; T2D type 2 diabetes mellitus; LDL-C low-density lipoprotein cholesterol; HDL-C high-density lipoprotein cholesterol; TC total cholesterol; TG triglyceride; GIANT Genetic Investigation of ANthropometric Traits; DIAGRAM DIAbetes Genetics Replication and Meta-analysis; GLGC global lipids genetics consortium; GSCAN GWAS & Sequencing Consortium of Alcohol and Nicotine use

ISSN: 1755-8794