Fig. 4

Functional enrichment analyses of DE-IRGs. A GO enrichment analysis with “eGO” function (OrgDb = org.Hs.eg.db, pvalueCutoff = 0.05, qvalueCutoff = 0.25, pAdjustMethod = "BH") in the clusterProfiler package. The results were visualized with the “cnetplot” function in the enrichplot package and the color of the dot marks the logFC of the gene. B GO enrichment analysis. The top 12 results were visualized with the “barplot” function in the enrichplot package. The x-axis and y-axis represent the gene ratio, and GO terms, respectively, and the color represents the corrected p value. C KEGG pathway enrichment analysis with “enrichKEGG” function (organism = "hsa", keyType = "kegg", pvalueCutoff = 0.05, pAdjustMethod = "fdr") in the clusterProfiler package. The top 12 results were visualized with the “dotplot” function in the enrichplot package and the x-axis and y-axis represent the gene ratio and pathway, respectively. D Correlation between KEGG enrichment pathways with the “upsetplot” function in the enrichplot package and the line represents the correlation between pathways