Fig. 1

Identification of ACOT7–NPHP4 in one patient with ALL. a May–Grunwald–Giemsa staining showed acute lymphoblastic leukemia blasts (87%) in a bone marrow (BM) smear with a magnification of 400. b Normal chromosomal karyotype with 46, XY. c The ACOT7–NPHP4 transcript contained ACOT7 exons 1–7 and NPHP4 exons 5–29. d PCR band (238 bp) and the fusion site by Sanger sequencing of ACOT7–NPHP4. Control: patient’s hair follicle sample. e The domains of the wild-type ACOT7 and NPHP4, and the domains of the ACOT7–NPHP4 fusion proteins were shown. Breakpoints were indicated by the black dotted lines. HD1: HotDog ACOT-type 1; HD2: HotDog ACOT-type 2; SBBL: a domain named sufficient for basal bodies localization