Fig. 1

Identify asparagine metabolism subtypes of HCC in TCGA database and validation in ICGC database. A Consensus Cumulative Distribution Function (CDF) Plot and relative change in the area under the CDF curve (CDF Delta area). B Consensus matrices of the TCGA cohort for k = 2. C The expression of asparagine metabolism genes in two HCC subgroups. D, E OS and DFS analyses of the two HCC subgroups in the TCGA database. F A 9-gene signature was constructed for the HCC cases in the ICGC database by Lasso Cox analysis. Risk scores distribution, survival status of each patient in the ICGC database, and heatmaps of signature gene expression were plotted. G OS analysis of the two HCC subgroups in the ICGC database. H The 1-, 3- and 5-year ROC curves of the gene signature. The AUC was indicated. I The relationship between partial likelihood deviation and log (λ), and the LASSO coefficient profiles of the fractions of 9 genes were plotted