Fig. 3

Chromosome 12 STR polymorphic markers analysis. (A) Ideogram showing five STR marker’s position on chromosome 12. Representative electropherograms of informative STR markers: (B) In patient 1, D12S1042 marker showed a dosage ratio F1 1.9:1 M1 (paternal allele F1: maternal allele M1); (C) In patient 2, a dosage ratio M2 2:1 F2 was observed for marker D12S374 (maternal allele M2: paternal allele F2) and (D) In patient 3, marker D12S1042 showed slightly different fluorescent activity with a dosage ratio M3 1.3:1 F3 (maternal allele M3: paternal allele F3). *Markers D12S398 in patients 1 and 3, as well as the marker D12S373 in patient 2, were considered non informative because of their homozygous status. **Father’s DNA sample was not suitable for molecular analysis