Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

Table 3 Association between PNPLA3 polymorphisms and HCC susceptibility

SNP_ID	Model	Genotype	Case	Control	Adjusted
SNP_ID	Model	Genotype	Case	Control	OR (95% CI)	p	FDR-p
rs738409	Co-dominant	CC	154	180	1
		CG	250	240	1.22(0.92–1.62)	0.160	0.214
		GG	79	62	1.49(1.00–2.22)	0.049	0.065
	Dominant	CC	154	180	1
	Dominant	CG + GG	329	302	1.28(0.98–1.67)	0.072	0.096
	Recessive	CC + CG	404	420	1
	Recessive	GG	79	62	1.33(0.92–1.91)	0.128	0.128
	Log-additive	–	–	–	1.22(1.01–1.48)	0.038	0.051
rs3747207	Co-dominant	GG	156	181	1
		GA	254	248	1.19(0.90–1.57)	0.216	0.216
		AA	74	242	1.48(0.99–2.23)	0.058	0.058
	Dominant	GG	156	181	1
	Dominant	GA + AA	328	306	1.25(0.96–1.63)	0.104	0.104
	Recessive	GG + GA	410	429	1
	Recessive	AA	74	58	1.34(0.92–1.94)	0.127	0.170
	Log-additive	–	–	–	1.21(1.00–1.47)	0.050	0.050
rs4823173	Co-dominant	GG	152	184	1
		GA	256	242	1.28(0.97–1.70)	0.075	0.150
		AA	75	56	1.63(1.08–2.46)	0.019	0.078
	Dominant	GG	152	184	1
	Dominant	GA + AA	331	298	1.35(1.04–1.77)	0.027	0.053
	Recessive	GG + GA	408	426	1
	Recessive	AA	75	56	1.40(0.96–2.04)	0.077	0.308
	Log-additive	–	–	–	1.28(1.06–1.55)	0.012	0.049
rs2896019	Co-dominant	TT	150	186	1
		TG	257	241	1.33(1.01–1.76)	0.045	0.181
		GG	76	60	1.59(1.06–2.39)	0.024	0.048
	Dominant	TT	150	186	1
	Dominant	TG + GG	333	301	1.38(1.06–1.81)	0.018	0.071
	Recessive	TT + TG	407	427	1
	Recessive	GG	76	60	1.34(0.93–1.94)	0.116	0.232
	Log-additive	–	–	–	1.28(1.06–1.55)	0.012	0.024

HCC hepatocellular carcinoma; SNP single nucleotide polymorphism; OR odds ratio; 95% CI 95% confidence interval; FDR false discovery rate
p-value was calculated by logistic regression analysis with adjustments for age, gender and smoking
Bold values indicate statistical significance

ISSN: 1755-8794