Fig. 5

The performance of HOXL score for ESCC classification. A The HOXL scores of normal, ESCC and ESCA samples. For two group comparisons, the Wilcoxon rank sum test was used. For three group comparison, the Kruskal test was used. The three lines from top to bottom in each category indicated the median and 90th percentile of scores. B ROC curves of HOXL-score for ESCC and ESCA classification. The points indicated the best cutoff of HOXL-scores, and the percentages were the best specificity and sensitivity estimated by Youden’s index