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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Construction and experimental validation of an acetylation-related gene signature to evaluate the recurrence and immunotherapeutic response in early-stage lung adenocarcinoma

Fig. 3

RBBP7 and YEATS2 were identified as the hub genes as the predictive biomarkers for the recurrence of early-stage LUAD patients. A The volcano plot indicated that a total of 152 acetylation-related genes were differentially expressed between 59 adjacent normal and 334 early-stage LUAD samples. B The PPI network of the DEGs. C The Top 30 genes with the highest degree value in the network. D Lasso regression identified 10 genes showing significant predictive value to RFS of early-stage LUAD. E The coefficients of the 10 genes in the Lasso regression. F Three genes were identified by the univariate Cox regression with P-value < 0.05 filtering. G RBBP7 and YEATS2 were con-determined by the Lasso regression and univariate Cox regression. LUAD lung adenocarcinoma, PPI protein–protein interaction, DEGs differentially-expressed genes, RFS recurrence-free survival, Lasso least absolute shrinkage and selection operator

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BMC Medical Genomics

ISSN: 1755-8794

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