Skip to main content
Fig. 4 | BMC Medical Genomics

Fig. 4

From: Construction and experimental validation of an acetylation-related gene signature to evaluate the recurrence and immunotherapeutic response in early-stage lung adenocarcinoma

Fig. 4

The external validation of RBBP7 and YEATS2. A The immunohistochemical staining showed that RBBP7 and YEATS2 were up-regulated in the LUAD samples compared with the normal lung tissue. B The RT-qPCR experiments showed that the expression levels of RBBP7 and YEATS2 in early-stage LUAD samples were higher than those in adjacent normal tissues in 23 clinical samples from the local hospital. C The predictive value of RBBP7 (up) and YEATS2 (down) to RFS in the TCGA cohort. The optimal cut-off was determined by the X-tile. D The expressions of RBBP7 and YEATS2 in human pulmonary alveolar epithelial cell line and LUAD cell lines, which were detected by RT-qPCR. E RT-qPCR experiments were carried out to verify the expression levels of YEATS2 in H1975 and HCC-827 cell lines transfected with si-NC or si-YEATS2. F–G The knockdown of YEATS2 significantly suppressed the proliferation of H1975 (F) and HCC-827 (G) cells. LUAD lung adenocarcinoma, RFS recurrence-free survival, OD optical density

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us