Fig. 1

Evaluation of the screened data. A Pearson correlation analysis. Each box represented one sample in different groups, and the decimal in the box was the correlation coefficient between different samples. The larger the number, the lighter the color of each box, which meant the higher the relevance. B Results of PCA. The red and black dots signified the individuals in the model and control group, respectively. The shorter the distance between samples in the same group and the more significant the separation between samples in different groups, while the more the reproducibility of the data and rationality of sample selection