Skip to main content

Table 4 Stratified analyses between PPARγ rs1801282 C > G polymorphism and GC risk by sex, age, smoking status, alcohol consumption and BMI

From: Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population

Variable

(Case/control)a

Adjusted ORb (95% CI); P

CC

GC

GG

Additive model

Homozygote model

Dominant model

Recessive model

Sex

       

 Male

301/892

26/103

1/3

0.68 (0.43–1.08) P: 0.102

1.07 (0.10–11.44) P: 0.959

0.69 (0.44–1.09) P: 0.109

1.10 (0.10–11.81) P: 0.938

 Female

151/425

8/48

0/1

0.47 (0.21–1.04) P: 0.061

– P: 0.989

0.47 (0.21–1.03) P: 0.058

– P: 0.990

Age

       

 < 61

206/622

14/59

0/2

0.66 (0.35–1.24) P: 0.196

– P: 0.981

0.63 (0.34–1.19) P: 0.155

P: 0.981

 ≥ 61

246/695

20/92

1/2

0.59 (0.35–0.98) P: 0.043

1.93 (0.17–22.23) P: 0.597

0.61 (0.37–1.01) P: 0.055

2.02 (0.18–23.22) P: 0.572

Smoking status

       

 Never

289/944

18/101

1/4

0.33 (0.33–0.95) P: 0.031

0.81 (0.08–8.10) P: 0.861

0.57 (0.34–0.95) P: 0.032

0.85 (0.09–8.48) P: 0.893

 Ever

163/373

16/50

0/0

0.72 (0.39–1.33) P: 0.288

0.72 (0.39–1.33) P: 0.288

Alcohol consumption

       

 Never

350/1180

21/133

1/3

0.51 (0.32–0.83) P: 0.006

1.62 (0.16–16.30) P: 0.682

0.53 (0.33–0.85) P: 0.008

1.71 (0.17–17.14) P: 0.650

 Ever

102/137

13/18

0/1

1.11 (0.51–2.43) P: 0.789

P: 0.986

1.03 (0.48–2.23) P: 0.941

P: 0.986

BMI (kg/m2)

       

 < 24

329/677

25/80

1/1

0.65 (0.40–1.04) P: 0.071

1.98 (0.11–34.90) P: 0.640

0.66 (0.41–1.06) P: 0.085

2.06 (0.12–36.28) P: 0.622

 ≥ 24

123/640

9/71

0/3

0.57 (0.28–1.19) P: 0.137

P: 0.984

0.55 (0.27–1.15) P: 0.113

P: 0.984

  1. Bold indicates statistical significance (P < 0.05)
  2. aThe genotyping was successful in 487 (99.39%) gastric cancer cases, and 1472 (99.73%) controls for PPARγ rs1801282 C > G
  3. bAdjusted for age, sex, BMI, smoking status, alcohol use and BMI (besides stratified factors accordingly) in a logistic regression model