Table 1 DB table from DSigDB
From: Relationship between drug targets and drug-signature networks: a network-based genome-wide landscape
Domain | Purpose |
|---|---|
D1 | A total of 1,202 Food and Drug Administration (FDA)-approved drugs including 1,288 target genes. Here drug-target gene refers to the gene-coded proteins that physically bind and interact with drug compounds |
D2 | In total, 1,220 kinase inhibitors (1,065 unique kinase inhibitors) covering 407 kinases that frequently mutate in various cancers |
D3 | Gene expression profiles obtained by induction with compounds. In total, 7,064 gene expression profiles were collected from three cancer cell lines perturbed by 1,309 compounds from CMap (build 02) [20]. Compounds that were profiled by multiple cell lines were unified and genes with > twofold change relative to the control (either up- or downregulation) were considered as gene sets |
D4 | In total, 10,830 and 5,163 gene sets were compiled from the Therapeutics Targets Database [21] and the Comparative Toxicogenomics Database [22], respectively, which were extracted from literature using a mixture of manual curation and text mining approaches |