Table 3 The association between these SNPs and TC risk
SNP | Model | Genotype | Cases | Controls | OR (95%CI) | P |
|---|---|---|---|---|---|---|
rs2048722 | Co-dominant | G/G | 99 (27.2%) | 143 (29.7%) | 1.00 | |
TPO | G/A | 174 (47.8%) | 233 (48.4%) | 1.08(0.78–1.49) | 0.636 | |
A/A | 91 (25.0%) | 105 (21.8%) | 1.25(0.85–1.83) | 0.254 | ||
Dominant | G/G | 99 (27.2%) | 143 (29.7%) | 1.00 | ||
G/A-A/A | 265 (72.8%) | 338 (70.3%) | 1.13(0.84–1.53) | 0.418 | ||
Recessive | G/G-G/A | 273 (75.0%) | 376 (78.2%) | 1.00 | ||
A/A | 91 (25.0%) | 105 (21.8%) | 1.19(0.86–1.64) | 0.294 | ||
Additive | – | – | – | 1.12(0.92–1.35) | 0.260 | |
rs925489 | Co-dominant | T/T | 280 (76.7%) | 418 (83.9%) | 1.00 | |
PTCSC2 | T/C | 83 (22.7%) | 78 (15.7%) | 1.59(1.12–2.24) | 0.009** | |
C/C | 2 (0.60%) | 2 (0.40%) | 1.43(0.20–10.27) | 0.721 | ||
Dominant | T/T | 280 (76.7%) | 418 (83.9%) | 1.00 | ||
T/C-C/C | 85 (23.3%) | 80 (16.1%) | 1.58(1.12–2.23) | 0.009** | ||
Recessive | T/T-T/C | 363 (99.5%) | 496 (99.6%) | 1.00 | ||
C/C | 2 (0.60%) | 2 (0.40%) | 1.31(0.18–9.41) | 0.786 | ||
Additive | – | – | 1.54(1.10–2.15) | 0.010* | ||
rs4919510 | Co-dominant | G/G | 118 (32.3%) | 135 (27.3%) | 1.00 | |
SEMA4G | G/C | 168 (46.0%) | 257 (51.9%) | 0.74(0.54–1.02) | 0.064 | |
C/C | 79 (21.6%) | 103 (20.8%) | 0.88(0.60–1.29) | 0.506 | ||
Dominant | G/G | 118 (32.3%) | 135 (27.3%) | 1.00 | ||
G/C-C/C | 247 (67.7%) | 360 (72.7%) | 0.78(0.58–1.05) | 0.102 | ||
Recessive | G/G-G/C | 286 (78.4%) | 392 (79.2%) | 1.00 | ||
C/C | 79 (21.6%) | 103 (20.8%) | 1.06(0.76–1.47) | 0.786 | ||
Additive | – | – | – | 0.92(0.76–1.11) | 0.385 |